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ADC Therapeutics SA (ADCT) Q4 2025 earnings results (fourth quarter 2025)

10-K filed Mar 10, 2026

ADC Therapeutics SA (ADCT) reported revenue of $23.1M for the fourth quarter 2025 (Q4 2025), +36% from a year earlier and +40% from the quarter before. Operating margin was -77.7%, net loss $6.4M (27.8% of revenue).

Revenue$23.1M
Year over year+36%
Quarter over quarter+40%
Operating margin-77.7%
Net earnings−$6.4M

ADC Therapeutics SA, Q4 2025: revenue $23.1M (+36% year over year), operating margin -77.7%, net loss $6.4M, operating cash flow −$31.1M. The chart follows the revenue to costs, profit and cash.

Q4 2025AmountQ/QY/Y
Revenue$23.1M+40%+36%
Operating profit−$17.9M——
Net earnings−$6.4M——
Operating cash flow−$31.1M——

What changed

Revenue was $23.1M in Q4 2025, up 36% year over year and up 40% from the previous quarter. Product revenues, net was the largest line at 97% of revenue.

Operating costs exceeded revenue by $17.9M, an operating margin of -77.7%. Total costs fell 17% while revenue rose 36%. The quarter ended with a net loss of $6.4M, narrower than the previous quarter's $41.0M loss. Non-operating items added $11.1M, -163% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was −$31.1M. Non-cash charges added back $673K of share-based compensation. Working capital and other items used $25.4M.

Questions

What was ADC Therapeutics SA's revenue in the fourth quarter 2025?

ADC Therapeutics SA (ADCT) reported revenue of $23.1M for the fourth quarter 2025 (Q4 2025), +36% from a year earlier and +40% from the quarter before.

Was ADC Therapeutics SA profitable in the fourth quarter 2025?

Operating loss was $17.9M (-77.7% of revenue) and net loss $6.4M.

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Source: ADC Therapeutics SA 10-K on SEC EDGAR.