Filing Flows › Agenus (AGEN) › Q4 2025
Agenus (AGEN) Q4 2025 earnings results (fourth quarter 2025)
10-K filed Mar 16, 2026
Agenus (AGEN) reported revenue of $34.2M for the fourth quarter 2025 (Q4 2025), +27% from a year earlier and +13% from the quarter before. Operating margin was 42.1%, net loss $10.6M (31.0% of revenue).
Agenus, Q4 2025: revenue $34.2M (+28% year over year), operating margin 42.1%, net loss $10.6M, operating cash flow −$16.6M. The chart follows the revenue to costs, profit and cash.
| Q4 2025 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $34.2M | +13% | +27% |
| Operating profit | $14.4M | — | — |
| Net earnings | −$10.6M | -117% | — |
| Operating cash flow | −$16.6M | — | — |
What changed
Revenue was $34.2M in Q4 2025, up 27% year over year and up 13% from the previous quarter.
Operating profit was $14.4M, a 42.1% margin (up 138.6 points year over year). Total costs fell 62% while revenue rose 27%. The quarter ended with a net loss of $10.6M, after a profit of $63.9M the previous quarter. Net interest and other expense of $25.0M was the main reason.
Operating cash flow was −$16.6M. Non-cash charges added back $597K of depreciation and amortization and $3.5M of share-based compensation. Working capital and other items used $10.1M.
Questions
What was Agenus' revenue in the fourth quarter 2025?
Agenus (AGEN) reported revenue of $34.2M for the fourth quarter 2025 (Q4 2025), +27% from a year earlier and +13% from the quarter before.
Was Agenus profitable in the fourth quarter 2025?
Operating profit was $14.4M (42.1% of revenue) and net loss $10.6M.
Source: Agenus 10-K on SEC EDGAR.