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Innoviva (INVA) Q4 2025 earnings results (fourth quarter 2025)

10-K filed Feb 25, 2026

Innoviva (INVA) reported revenue of $115M for the fourth quarter 2025 (Q4 2025), +25% from a year earlier and +6% from the quarter before. Operating margin was 34.0%, net earnings $164M (143.2% of revenue).

Revenue$115M
Year over year+25%
Quarter over quarter+6%
Operating margin34.0%
Net earnings$164M

Innoviva, Q4 2025: revenue $115M (+25% year over year), operating margin 34.0%, net earnings $164M, operating cash flow $54.5M. The chart follows the revenue to costs, profit and cash.

Q4 2025AmountQ/QY/Y
Revenue$115M+6%+25%
Gross profit$75.7M+0.2%-3%
Operating profit$39.0M+13%-10%
Net earnings$164M+83%+707%
Operating cash flow$54.5M+10%-8%
Free cash flow$54.5M+12%-8%

What changed

Revenue was $114.6M in Q4 2025, up 25% year over year and up 6% from the previous quarter. Royalty was the largest line at 48% of revenue.

Gross margin was 66.0%, down 19.1 points from a year earlier. Operating profit was $39.0M, a 34.0% margin (down 13.0 points year over year). Operating profit fell $4.2M even though revenue rose $22.8M versus a year earlier, so costs grew faster than sales. Operating expenses grew 5% against revenue growth of 25%. The fastest-growing cost line was Research & development (+24%). Net earnings were $164.2M, up 707% year over year. The effective tax rate was 15.8%. Non-operating items added $156.0M, 80% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was $54.5M (down 8% year over year), 33% of net earnings. Non-cash charges added back $2.5M of share-based compensation. Working capital and other items used $112.1M. Capital expenditures of $10K left free cash flow of $54.5M.

Questions

What was Innoviva's revenue in the fourth quarter 2025?

Innoviva (INVA) reported revenue of $115M for the fourth quarter 2025 (Q4 2025), +25% from a year earlier and +6% from the quarter before.

Was Innoviva profitable in the fourth quarter 2025?

Operating profit was $39.0M (34.0% of revenue) and net earnings $164M.

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Source: Innoviva 10-K on SEC EDGAR.