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Kiniksa Pharmaceuticals International (KNSA) Q4 2025 earnings results (fourth quarter 2025)

10-K filed Feb 24, 2026

Kiniksa Pharmaceuticals International (KNSA) reported revenue of $202M for the fourth quarter 2025 (Q4 2025), +65% from a year earlier and +12% from the quarter before. Operating margin was 9.8%, net earnings $14.2M (7.0% of revenue).

Revenue$202M
Year over year+65%
Quarter over quarter+12%
Operating margin9.8%
Net earnings$14.2M

Kiniksa Pharmaceuticals International, Q4 2025: revenue $202M (+65% year over year), operating margin 9.8%, net earnings $14.2M, operating cash flow $53.9M. The chart follows the revenue to costs, profit and cash.

Q4 2025AmountQ/QY/Y
Revenue$202M+12%+65%
Operating profit$19.8M-18%—
Net earnings$14.2M-23%—
Operating cash flow$53.9M+60%+187%
Free cash flow$53.3M+61%+187%

What changed

Revenue was $202.1M in Q4 2025, up 65% year over year and up 12% from the previous quarter.

Operating profit was $19.8M, a 9.8% margin (up 25.5 points year over year). Total costs grew 29% against revenue growth of 65%. The fastest-growing cost line was Other operating costs (+45%). Net earnings were $14.2M. The effective tax rate was 39.0%.

Operating cash flow was $53.9M (up 187% year over year), 380% of net earnings. Non-cash charges added back $467K of depreciation and amortization and $10.2M of share-based compensation. Working capital and other items added $29.0M. Capital expenditures of $633K left free cash flow of $53.3M.

Questions

What was Kiniksa Pharmaceuticals International's revenue in the fourth quarter 2025?

Kiniksa Pharmaceuticals International (KNSA) reported revenue of $202M for the fourth quarter 2025 (Q4 2025), +65% from a year earlier and +12% from the quarter before.

Was Kiniksa Pharmaceuticals International profitable in the fourth quarter 2025?

Operating profit was $19.8M (9.8% of revenue) and net earnings $14.2M.

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Source: Kiniksa Pharmaceuticals International 10-K on SEC EDGAR.