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Who owns Karyopharm Therapeutics (KPTI) stock

91 funds reported Karyopharm Therapeutics (KPTI) shares in their latest 13F filings, worth $212M in all. The largest holder is RA Capital Management, L.P. ($18.7M). Last quarter 59 funds added to their stakes and 27 cut them.

Largest holders of KPTI (13F)Largest holders of KPTI (13F)RA Capital Management, L.P.$18.7MAdage Capital Partners GP, L.L.C.$14.9MAcorn Capital Advisors, LLC$14.8MGoldman Sachs Group$13.9MBlackRock$13.9MKalehua Capital Management LLC$13.4MVanguard Capital Management LLC$9.4MCatalio Capital Management, LP$9.2MAvidity Partners Management LP$9.0MT. Rowe Price Investment Manageme…$7.7M

Largest holders (13F)

FundSharesValueChangeQuarter
RA Capital Management, L.P.1,917,354$18.7Munchanged2026-06-30
Adage Capital Partners GP, L.L.C.1,521,322$14.9Mdecrease2026-06-30
Acorn Capital Advisors, LLC1,518,113$14.8Mincrease2026-06-30
Goldman Sachs Group1,424,658$13.9Mincrease2026-06-30
BlackRock1,418,799$13.9Mincrease2026-06-30
Kalehua Capital Management LLC1,371,288$13.4Mnew2026-06-30
Vanguard Capital Management LLC958,979$9.4Mincrease2026-06-30
Catalio Capital Management, LP940,855$9.2Mincrease2026-06-30
Avidity Partners Management LP924,487$9.0Mdecrease2026-06-30
T. Rowe Price Investment Management786,309$7.7Mdecrease2026-06-30
Two Sigma Investments, LP695,264$6.8Mincrease2026-06-30
NEA Management Company, LLC576,780$5.6Mnew2026-06-30
Geode Capital Management, LLC531,231$5.2Mincrease2026-06-30
Ghisallo Capital Management LLC500,000$4.9Mnew2026-06-30
Soleus Capital Management, L.P.440,000$4.3Munchanged2026-06-30

Karyopharm Therapeutics' latest quarter

Karyopharm Therapeutics, Q2 2026: revenue $33.4M (-12% year over year), operating margin -67.4%, net loss $67.0M, operating cash flow −$24.9M. The chart follows the revenue to costs, profit and cash.

Questions

Who owns the most KPTI stock?

By the latest 13F filings: RA Capital Management, L.P. ($18.7M); Adage Capital Partners GP, L.L.C. ($14.9M); Acorn Capital Advisors, LLC ($14.8M); Goldman Sachs Group ($13.9M); BlackRock ($13.9M).

What is the short interest in KPTI?

7,266,973 shares were sold short at the 2026-10-15 settlement, 19.99% of the float.

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Updated Nov 8, 2026. Read automatically from SEC filings and public data; errors are possible. Not investment advice.