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Macrogenics (MGNX) Q2 2025 earnings results (second quarter 2025)

10-Q filed Aug 14, 2025

Macrogenics (MGNX) reported revenue of $22.2M for the second quarter 2025 (Q2 2025), +106% from a year earlier and +69% from the quarter before. Operating margin was -165.3%, net loss $36.3M (163.0% of revenue).

Revenue$22.2M
Year over year+106%
Quarter over quarter+69%
Operating margin-165.3%
Net earnings−$36.3M

Macrogenics, Q2 2025: revenue $22.2M (+106% year over year), operating margin -165.3%, net loss $36.3M, operating cash flow −$47.0M. The chart follows the revenue to costs, profit and cash.

Q2 2025AmountQ/QY/Y
Revenue$22.2M+69%+106%
Operating profit−$36.8M——
Net earnings−$36.3M——
Operating cash flow−$47.0M——

What changed

Revenue was $22.2M in Q2 2025, up 106% year over year and up 69% from the previous quarter.

Operating costs exceeded revenue by $36.8M, an operating margin of -165.3%. Total costs fell 14% while revenue rose 106%. The fastest-growing cost line was Other operating costs (+236%). The quarter ended with a net loss of $36.3M, narrower than the previous quarter's $41.0M loss.

Operating cash flow was −$47.0M. Non-cash charges added back $1.9M of depreciation and amortization and $3.7M of share-based compensation. Working capital and other items used $16.3M. Capital expenditures of $715K exceeded it, leaving free cash flow of −$47.7M.

Questions

What was Macrogenics' revenue in the second quarter 2025?

Macrogenics (MGNX) reported revenue of $22.2M for the second quarter 2025 (Q2 2025), +106% from a year earlier and +69% from the quarter before.

Was Macrogenics profitable in the second quarter 2025?

Operating loss was $36.8M (-165.3% of revenue) and net loss $36.3M.

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Source: Macrogenics 10-Q on SEC EDGAR.