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Who owns Orchestra BioMed Holdings (OBIO) stock

77 funds reported Orchestra BioMed Holdings (OBIO) shares in their latest 13F filings, worth $127M in all. The largest holder is RTW Investments, LP ($41.2M). Last quarter 42 funds added to their stakes and 28 cut them.

Largest holders of OBIO (13F)Largest holders of OBIO (13F)RTW Investments, LP$41.2MPerceptive Advisors LLC$21.7MBlackRock$10.8MVanguard Capital Management LLC$8.7MVanguard Group$6.7MGeode Capital Management, LLC$4.4MAlyeska Investment Group, L.P.$4.3MPropel Bio Management, LLC$3.9MUBS AM, a distinct business unit …$2.8MState Street$2.2M

Largest holders (13F)

FundSharesValueChangeQuarter
RTW Investments, LP9,556,063$41.2Mincrease2026-06-30
Perceptive Advisors LLC5,037,906$21.7Munchanged2026-06-30
BlackRock2,510,387$10.8Mincrease2026-06-30
Vanguard Capital Management LLC2,022,916$8.7Mdecrease2026-06-30
Vanguard Group1,604,556$6.7Mincrease2025-12-31
Geode Capital Management, LLC1,007,908$4.4Mincrease2026-06-30
Alyeska Investment Group, L.P.1,000,000$4.3Munchanged2026-06-30
Propel Bio Management, LLC896,701$3.9Mnew2026-06-30
UBS AM, a distinct business unit of UBS Asset Management Americas LLC642,154$2.8Mnew2026-06-30
State Street516,050$2.2Mincrease2026-06-30
Rice Hall James & Associates, LLC424,000$1.8Mincrease2026-06-30
Charles Schwab Investment Management349,544$1.5Mincrease2026-06-30
Northern Trust343,640$1.5Mincrease2026-06-30
UBS Group AG325,773$1.4Mincrease2026-06-30
Simplify Asset Management219,387$1.4Munchanged2026-09-30

Orchestra BioMed Holdings' latest quarter

Orchestra BioMed Holdings, Q2 2026: revenue $88K (-90% year over year), net loss $23.8M, operating cash flow −$19.3M. The chart follows the revenue to costs, profit and cash.

Questions

Who owns the most OBIO stock?

By the latest 13F filings: RTW Investments, LP ($41.2M); Perceptive Advisors LLC ($21.7M); BlackRock ($10.8M); Vanguard Capital Management LLC ($8.7M); Vanguard Group ($6.7M).

What is the short interest in OBIO?

2,552,988 shares were sold short at the 2026-10-15 settlement, 0.23% of the float.

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Updated Nov 8, 2026. Read automatically from SEC filings and public data; errors are possible. Not investment advice.