Filing Flows › Opko Health (OPK) › Q4 2025
Opko Health (OPK) Q4 2025 earnings results (fourth quarter 2025)
10-K filed Feb 26, 2026
Opko Health (OPK) reported revenue of $148M for the fourth quarter 2025 (Q4 2025), -19% from a year earlier and -2% from the quarter before. Operating margin was -25.8%, net loss $31.3M (21.1% of revenue).
Opko Health, Q4 2025: revenue $148M (-19% year over year), operating margin -25.8%, net loss $31.3M, operating cash flow −$25.9M. The chart follows the revenue to costs, profit and cash.
| Q4 2025 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $148M | -2% | -19% |
| Operating profit | −$38.3M | -180% | — |
| Net earnings | −$31.3M | -245% | — |
| Operating cash flow | −$25.9M | — | — |
What changed
Revenue was $148.5M in Q4 2025, down 19% year over year and down 2% from the previous quarter. Service was the largest line at 48% of revenue.
Gross margin was 43.1%, down 3.0 points from a year earlier. Operating costs exceeded revenue by $38.3M, an operating margin of -25.8%. Operating expenses fell 13% while revenue fell 19%. The quarter ended with a net loss of $31.3M, after a profit of $21.6M the previous quarter.
Operating cash flow was −$25.9M. Non-cash charges added back $22.4M of depreciation and amortization and $2.9M of share-based compensation. Working capital and other items used $20.0M. Capital expenditures of $2.7M exceeded it, leaving free cash flow of −$28.6M.
Questions
What was Opko Health's revenue in the fourth quarter 2025?
Opko Health (OPK) reported revenue of $148M for the fourth quarter 2025 (Q4 2025), -19% from a year earlier and -2% from the quarter before.
Was Opko Health profitable in the fourth quarter 2025?
Operating loss was $38.3M (-25.8% of revenue) and net loss $31.3M.
Source: Opko Health 10-K on SEC EDGAR.