Filing Flows › Prime Medicine (PRME) › Q4 2025 › vs Q3 2025
Prime Medicine (PRME) Q4 2025 vs Q3 2025 (quarter over quarter)
Prime Medicine's revenue fell $387K (-32%) from $1.2M in Q3 2025 to $838K in Q4 2025.
Prime Medicine, Q4 2025: revenue $838K (-62% year over year), net loss $46.1M, operating cash flow −$37.3M. The chart draws each line against Q3 2025, the increases inside each band.
Every line
| Line | Q4 2025 | Q3 2025 | Change | % |
|---|---|---|---|---|
| Revenue | $838K | $1.2M | −$387K | -32% |
| Other income, net | $2.5M | $3.4M | −$862K | -25% |
| Net loss | $46.1M | $50.6M | −$4.5M | -9% |
| Costs & expenses | $49.4M | $55.2M | −$5.8M | -10% |
| Operating costs | $49.4M | $55.2M | −$5.8M | -10% |
| Research & development | $34.7M | $44.0M | −$9.3M | -21% |
| General & admin | $14.7M | $11.2M | $3.5M | +31% |
| Operating cash sources | $46.1M | $50.6M | −$4.5M | -9% |
| Depreciation & amortization | $1.9M | $1.9M | −$5K | -0.3% |
| Share-based compensation | $4.5M | $12.7M | −$8.2M | -65% |
| Working capital & other | $2.4M | $915K | $1.5M | +166% |
| Cash used in operations | $37.3M | $35.0M | $2.2M | +6% |
| Net loss absorbed | $46.1M | $50.6M | −$4.5M | -9% |
Questions
How much did Prime Medicine's revenue grow quarter over quarter in Q4 2025?
Prime Medicine's revenue fell $387K (-32%) from $1.2M in Q3 2025 to $838K in Q4 2025.