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Protagonist Therapeutics (PTGX) Q1 2025 earnings results (first quarter 2025)

10-Q filed May 6, 2025

Protagonist Therapeutics (PTGX) reported revenue of $28.3M for the first quarter 2025 (Q1 2025), -89% from a year earlier and -83% from the quarter before. Operating margin was -68.2%, net loss $11.7M (41.2% of revenue).

Revenue$28.3M
Year over year-89%
Quarter over quarter-83%
Operating margin-68.2%
Net earnings−$11.7M

Protagonist Therapeutics, Q1 2025: revenue $28.3M (-89% year over year), operating margin -68.2%, net loss $11.7M, operating cash flow $125M. The chart follows the revenue to costs, profit and cash.

Q1 2025AmountQ/QY/Y
Revenue$28.3M-83%-89%
Operating profit−$19.3M——
Net earnings−$11.7M——
Operating cash flow$125M——
Free cash flow$125M——

What changed

Revenue was $28.3M in Q1 2025, down 89% year over year and down 83% from the previous quarter.

Operating costs exceeded revenue by $19.3M, an operating margin of -68.2%. Total costs fell 2% while revenue fell 89%. The quarter ended with a net loss of $11.7M, after a profit of $131.7M the previous quarter. Non-operating items added $7.7M, -66% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was $125.4M. Non-cash charges added back $239K of depreciation and amortization and $13.8M of share-based compensation. Working capital and other items added $123.0M. Capital expenditures of $545K left free cash flow of $124.8M.

Questions

What was Protagonist Therapeutics' revenue in the first quarter 2025?

Protagonist Therapeutics (PTGX) reported revenue of $28.3M for the first quarter 2025 (Q1 2025), -89% from a year earlier and -83% from the quarter before.

Was Protagonist Therapeutics profitable in the first quarter 2025?

Operating loss was $19.3M (-68.2% of revenue) and net loss $11.7M.

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Source: Protagonist Therapeutics 10-Q on SEC EDGAR.