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Protagonist Therapeutics (PTGX) Q1 2026 earnings results (first quarter 2026)

10-Q filed May 5, 2026

Protagonist Therapeutics (PTGX) reported revenue of $56.4M for the first quarter 2026 (Q1 2026), +99% from a year earlier and +658% from the quarter before. Operating margin was -6.5%, net earnings $3.8M (6.7% of revenue).

Revenue$56.4M
Year over year+99%
Quarter over quarter+658%
Operating margin-6.5%
Net earnings$3.8M

Protagonist Therapeutics, Q1 2026: revenue $56.4M (+99% year over year), operating margin -6.5%, net earnings $3.8M, operating cash flow −$48.9M. The chart follows the revenue to costs, profit and cash.

Q1 2026AmountQ/QY/Y
Revenue$56.4M+658%+99%
Operating profit−$3.6M——
Net earnings$3.8M——
Operating cash flow−$48.9M—-139%

What changed

Revenue was $56.4M in Q1 2026, up 99% year over year and up 658% from the previous quarter.

Operating costs exceeded revenue by $3.6M, an operating margin of -6.5%. Total costs grew 26% against revenue growth of 99%. The fastest-growing cost line was Research & development (+30%). Net earnings were $3.8M. The effective tax rate was -65.8%. Non-operating items added $5.9M, 260% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was −$48.9M. Non-cash charges added back $407K of depreciation and amortization and $14.5M of share-based compensation. Working capital and other items used $67.7M. Capital expenditures of $215K exceeded it, leaving free cash flow of −$49.2M.

Questions

What was Protagonist Therapeutics' revenue in the first quarter 2026?

Protagonist Therapeutics (PTGX) reported revenue of $56.4M for the first quarter 2026 (Q1 2026), +99% from a year earlier and +658% from the quarter before.

Was Protagonist Therapeutics profitable in the first quarter 2026?

Operating loss was $3.6M (-6.5% of revenue) and net earnings $3.8M.

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Source: Protagonist Therapeutics 10-Q on SEC EDGAR.