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Protagonist Therapeutics (PTGX) Q3 2026 earnings results (third quarter 2026)

10-Q filed Nov 6, 2026

Protagonist Therapeutics (PTGX) reported revenue of $274M for the third quarter 2026 (Q3 2026), up 58-fold from a year earlier and +29% from the quarter before. Operating margin was 79.6%, net earnings $220M (80.2% of revenue).

Revenue$274M
Year over year58×
Quarter over quarter+29%
Operating margin79.6%
Net earnings$220M

Protagonist Therapeutics, Q3 2026: revenue $274M (58× year over year), operating margin 79.6%, net earnings $220M, operating cash flow −$23.2M. The chart follows the revenue to costs, profit and cash.

Q3 2026AmountQ/QY/Y
Revenue$274M+29%58×
Operating profit$218M+38%—
Net earnings$220M+35%—
Operating cash flow−$23.2M-111%—

What changed

Revenue was $274.4M in Q3 2026, up 5724% year over year and up 29% from the previous quarter.

Operating profit was $218.3M, a 79.6% margin (up 1064.7 points year over year). Total costs grew 10% against revenue growth of 5724%. The fastest-growing cost line was General & admin (+23%). Net earnings were $220.0M. The effective tax rate was 2.9%.

Operating cash flow was −$23.2M. Non-cash charges added back $409K of depreciation and amortization and $14.4M of share-based compensation. Working capital and other items used $258.0M. Capital expenditures of $237K exceeded it, leaving free cash flow of −$23.5M.

Questions

What was Protagonist Therapeutics' revenue in the third quarter 2026?

Protagonist Therapeutics (PTGX) reported revenue of $274M for the third quarter 2026 (Q3 2026), up 58-fold from a year earlier and +29% from the quarter before.

Was Protagonist Therapeutics profitable in the third quarter 2026?

Operating profit was $218M (79.6% of revenue) and net earnings $220M.

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Source: Protagonist Therapeutics 10-Q on SEC EDGAR.