Filing Flows › uniQure N.V. (QURE) › Q4 2025
uniQure N.V. (QURE) Q4 2025 earnings results (fourth quarter 2025)
10-K filed Mar 2, 2026
uniQure N.V. (QURE) reported revenue of $5.6M for the fourth quarter 2025 (Q4 2025), +7% from a year earlier and +50% from the quarter before. Operating margin was -918.1%, net loss $37.1M (666.1% of revenue).
uniQure N.V., Q4 2025: revenue $5.6M (+7% year over year), operating margin -918.1%, net loss $37.1M, operating cash flow −$77.6M. The chart follows the revenue to costs, profit and cash.
| Q4 2025 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $5.6M | +50% | +7% |
| Operating profit | −$51.1M | — | — |
| Net earnings | −$37.1M | — | — |
| Operating cash flow | −$77.6M | — | — |
What changed
Revenue was $5.6M in Q4 2025, up 7% year over year and up 50% from the previous quarter. License revenues was the largest line at 99% of revenue.
Operating costs exceeded revenue by $51.1M, an operating margin of -918.1%. Total costs grew 11% against revenue growth of 7%. The fastest-growing cost line was SG&A (+90%). The quarter ended with a net loss of $37.1M, narrower than the previous quarter's $80.5M loss. Non-operating items added $10.1M, -25% of pre-tax earnings, so the bottom line overstates operating performance.
Operating cash flow was −$77.6M. Non-cash charges added back $3.0M of depreciation and amortization and $4.7M of share-based compensation. Working capital and other items used $48.1M. Capital expenditures of $119K exceeded it, leaving free cash flow of −$77.7M.
Questions
What was uniQure N.V.'s revenue in the fourth quarter 2025?
uniQure N.V.
Was uniQure N.V. profitable in the fourth quarter 2025?
Operating loss was $51.1M (-918.1% of revenue) and net loss $37.1M.
Source: uniQure N.V. 10-K on SEC EDGAR.