Filing Flows › Septerna (SEPN) › Q1 2026 › vs Q4 2025
Septerna (SEPN) Q1 2026 vs Q4 2025 (quarter over quarter)
Septerna's revenue rose $2.4M (+10%) from $24.1M in Q4 2025 to $26.5M in Q1 2026.
Septerna, Q1 2026: revenue $26.5M (121× year over year), operating margin -50.1%, net loss $8.6M, operating cash flow −$25.6M. The chart draws each line against Q4 2025, the increases inside each band.
Every line
| Line | Q1 2026 | Q4 2025 | Change | % |
|---|---|---|---|---|
| Revenue | $26.5M | $24.1M | $2.4M | +10% |
| Other income, net | $5.0M | $5.3M | −$297K | -6% |
| Net loss | $8.6M | $10.7M | −$2.1M | -20% |
| Costs & expenses | $40.2M | $40.2M | $7K | 0% |
| Operating costs | $39.8M | $40.1M | −$318K | -0.8% |
| Income tax | $337K | $12K | $325K | 28× |
| Research & development | $29.5M | $31.9M | −$2.3M | -7% |
| General & admin | $10.3M | $8.3M | $2.0M | +24% |
| Operating cash sources | $32.1M | $18.0M | $14.0M | +78% |
| Depreciation & amortization | $421K | $401K | $20K | +5% |
| Share-based compensation | $6.0M | $2.7M | $3.4M | +126% |
| Cash used in operations | $25.6M | $15.0M | $10.6M | +71% |
| Net loss absorbed | $8.6M | $10.7M | −$2.1M | -20% |
| Working capital & other | $23.4M | $7.3M | $16.1M | +221% |
Questions
How much did Septerna's revenue grow quarter over quarter in Q1 2026?
Septerna's revenue rose $2.4M (+10%) from $24.1M in Q4 2025 to $26.5M in Q1 2026.