Filing Flows › Septerna (SEPN) › Q2 2026
Septerna (SEPN) Q2 2026 earnings results (second quarter 2026)
10-Q filed Aug 10, 2026
Septerna (SEPN) reported revenue of $26.7M for the second quarter 2026 (Q2 2026), up 225-fold from a year earlier and +0.8% from the quarter before. Operating margin was -62.9%, net loss $13.0M (48.7% of revenue).
Septerna, Q2 2026: revenue $26.7M (225× year over year), operating margin -62.9%, net loss $13.0M, operating cash flow −$22.2M. The chart follows the revenue to costs, profit and cash.
| Q2 2026 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $26.7M | +0.8% | 225× |
| Operating profit | −$16.8M | — | — |
| Net earnings | −$13.0M | — | — |
| Operating cash flow | −$22.2M | — | — |
What changed
Revenue was $26.7M in Q2 2026, up 22376% year over year and up 1% from the previous quarter.
Operating costs exceeded revenue by $16.8M, an operating margin of -62.9%. Total costs grew 50% against revenue growth of 22376%. The fastest-growing cost line was Research & development (+58%). The quarter ended with a net loss of $13.0M, wider than the previous quarter's $8.6M loss. Non-operating items added $4.8M, -40% of pre-tax earnings, so the bottom line overstates operating performance.
Operating cash flow was −$22.2M. Non-cash charges added back $427K of depreciation and amortization and $5.1M of share-based compensation. Working capital and other items used $14.6M.
Questions
What was Septerna's revenue in the second quarter 2026?
Septerna (SEPN) reported revenue of $26.7M for the second quarter 2026 (Q2 2026), up 225-fold from a year earlier and +0.8% from the quarter before.
Was Septerna profitable in the second quarter 2026?
Operating loss was $16.8M (-62.9% of revenue) and net loss $13.0M.
Source: Septerna 10-Q on SEC EDGAR.