Filing Flows › Upstream Bio (UPB) › Q1 2026 › vs Q1 2025
Upstream Bio (UPB) Q1 2026 vs Q1 2025 (year over year)
Upstream Bio's revenue rose $468K (+83%) from $566K in Q1 2025 to $1.0M in Q1 2026.
Upstream Bio, Q1 2026: revenue $1.0M (+83% year over year), net loss $40.6M, operating cash flow −$47.9M. The chart draws each line against Q1 2025, the increases inside each band.
Every line
| Line | Q1 2026 | Q1 2025 | Change | % |
|---|---|---|---|---|
| Revenue | $1.0M | $566K | $468K | +83% |
| Other income, net | $3.0M | $4.7M | −$1.7M | -36% |
| Net loss | $40.6M | $27.3M | $13.3M | +49% |
| Costs & expenses | $44.6M | $32.6M | $12.1M | +37% |
| Operating costs | $44.6M | $32.6M | $12.1M | +37% |
| Research & development | $36.6M | $25.8M | $10.8M | +42% |
| General & admin | $8.1M | $6.8M | $1.3M | +19% |
| Operating cash sources | $52.5M | $43.8M | $8.7M | +20% |
| Depreciation & amortization | $49K | $43K | $6K | +14% |
| Share-based compensation | $4.6M | $2.6M | $2.0M | +76% |
| Cash used in operations | $47.9M | $41.2M | $6.7M | +16% |
| Net loss absorbed | $40.6M | $27.3M | $13.3M | +49% |
| Working capital & other | $12.0M | $16.6M | −$4.6M | -28% |
Questions
How much did Upstream Bio's revenue grow year over year in Q1 2026?
Upstream Bio's revenue rose $468K (+83%) from $566K in Q1 2025 to $1.0M in Q1 2026.