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Xilio Therapeutics (XLO) Q2 2026 earnings results (second quarter 2026)

10-Q filed Aug 12, 2026

Xilio Therapeutics (XLO) reported revenue of $18.7M for the second quarter 2026 (Q2 2026), +131% from a year earlier and +48% from the quarter before. Operating margin was -18.7%, net loss $6.4M (34.1% of revenue).

Revenue$18.7M
Year over year+131%
Quarter over quarter+48%
Operating margin-18.7%
Net earnings−$6.4M

Xilio Therapeutics, Q2 2026: revenue $18.7M (+131% year over year), operating margin -18.7%, net loss $6.4M, operating cash flow −$18.8M. The chart follows the revenue to costs, profit and cash.

Q2 2026AmountQ/QY/Y
Revenue$18.7M+48%+131%
Operating profit−$3.5M——
Net earnings−$6.4M——
Operating cash flow−$18.8M——

What changed

Revenue was $18.7M in Q2 2026, up 131% year over year and up 48% from the previous quarter.

Operating costs exceeded revenue by $3.5M, an operating margin of -18.7%. Total costs fell 1% while revenue rose 131%. The quarter ended with a net loss of $6.4M, narrower than the previous quarter's $9.5M loss.

Operating cash flow was −$18.8M. Non-cash charges added back $331K of depreciation and amortization and $1.6M of share-based compensation. Working capital and other items used $14.3M. Capital expenditures of $19K exceeded it, leaving free cash flow of −$18.8M.

Questions

What was Xilio Therapeutics' revenue in the second quarter 2026?

Xilio Therapeutics (XLO) reported revenue of $18.7M for the second quarter 2026 (Q2 2026), +131% from a year earlier and +48% from the quarter before.

Was Xilio Therapeutics profitable in the second quarter 2026?

Operating loss was $3.5M (-18.7% of revenue) and net loss $6.4M.

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Source: Xilio Therapeutics 10-Q on SEC EDGAR.