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Zentalis Pharmaceuticals (ZNTL) earnings and revenue breakdown

Latest: Q4 2024 · 10-K filed Mar 26, 2025 · Zentalis Pharmaceuticals (ZNTL) Q4 2024 earnings results →

Q4 2024 177¢ of every $1 of revenue lost · operating margin -185.6%

Zentalis Pharmaceuticals made $26.9M in Q4 2024. Operating margin -185.6%, net loss $47.5M. See where every dollar goes — costs, profit and cash — as a Sankey from the 10-K filed Mar 26, 2025.

Revenue$26.9M
Year over year—
Operating margin-185.6%
Net earnings−$47.5M
Operating cash flow−$39.7M

Drawing the Sankey…

Open the interactive Sankey → click any line for what the company wrote about it, compare Y/Y and Q/Q, export as PNG or PDF

What changed this quarter

Revenue was $26.9M in Q4 2024.

Operating costs exceeded revenue by $49.8M, an operating margin of -185.6%. The quarter ended with a net loss of $47.5M.

Operating cash flow was −$39.7M. Non-cash charges added back $317K of depreciation and amortization and $31.4M of share-based compensation. Working capital and other items used $23.9M.

Quarterly history

QuarterFormFiledRevenueY/YOp. marginNet earningsOp. cash flow
Q4 202410-KMar 26, 2025$26.9M—-185.6%−$47.5M−$39.7M

Charts

Zentalis Pharmaceuticals: where the cash came from (+) and went (−), TTM to Q2 2026Zentalis Pharmaceuticals: where the cash came from (+) and went (−), TTM to Q2 2026Operating cash flow−$128MOther investing$121MCash drawn (+) / kept (−)$12.8MOther financing−$6.0MShares issued$511KAsset & business sales$129KCapital spending−$34K
From the cash-flow statement as filed (SEC XBRL). Cash is fungible: the bars do not say which dollar paid for what.
Zentalis Pharmaceuticals: profit against cash, quarter by quarterZentalis Pharmaceuticals: profit against cash, quarter by quarterNet incomeOperating cash flow−$40.2M−$44.0MQ3 2024−$47.5M−$39.7MQ4 2024−$48.3M−$32.6MQ1 2025−$26.9M−$34.7MQ2 2025−$26.7M−$27.0MQ3 2025−$35.2M−$30.9MQ4 2025−$35.4M−$33.0MQ1 2026−$42.3M−$37.2MQ2 2026
Latest (Q2 2026): Net income −$42.3M, Operating cash flow −$37.2M.
Zentalis Pharmaceuticals: diluted shares by fiscal yearZentalis Pharmaceuticals: diluted shares by fiscal year28MFY202043MFY202153MFY202265MFY202371MFY202472MFY2025
+155.6% since FY2020: more shares outstanding (issuance, stock pay).

Interactive views

The same charts as the app — open one to draw it.

💵Where each $1 goesinteractive

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🌏Named in Asian annual reportsinteractive

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🔄Rotation against the market and its industry (RRG)interactive

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🔍Earnings qualityinteractive

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⚖️Fair value by methodinteractive

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🔭Outlook & guidanceinteractive

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📈Investments: gains and what it boughtinteractive

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🏭Its industry’s money flow (input-output)interactive

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About Zentalis Pharmaceuticals

We are a clinical-stage biopharmaceutical company developing azenosertib (ZN-c3), a potentially first-in-class and best-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types. We are currently focused on advancing the clinical development of azenosertib in Cyclin E1+ platinum-resistant ovarian cancer, or PROC. We believe that our DENALI (ZN-c3-005) Part 2 clinical trial of azenosertib in patients with Cyclin E1+ PROC, if successful, has the potential to support an accelerated approval, subject to U.S. Food and Drug Administration, or FDA, review. Azenosertib also has broad franchise potential beyond Cyclin E1+ PROC. We exclusively in-license or solely own worldwide development and commercialization rights to azenosertib.

In its own words, from its 10-K, filed Mar 26, 2025.

Zentalis Pharmaceuticals against its Pharmaceutical Preparations peers

The largest companies of the same SEC industry, each at its latest quarter. Operating margin: -185.6% against the peers' median 20.4%.

CompanyQuarterRevenueY/YOp. margin
ZNTL Zentalis PharmaceuticalsQ4 2024$26.9M—-185.6%
JNJ Johnson & JohnsonQ3 2026$25.4B+6%0.1%
LLY ELI LillyQ3 2026$24.4B+39%34.5%
MRK MerckQ3 2026$18.1B+5%30.7%
ABBV AbbVieQ3 2026$17.4B+10%36.0%
PFE PfizerQ3 2026$16.6B-0.4%20.4%
BMY Bristol Myers SquibbQ3 2026$13.1B+7%19.4%
ABT Abbott LaboratoriesQ3 2026$13.0B+14%10.4%
REGN Regeneron PharmaceuticalsQ3 2026$5.1B+36%40.0%

Source: Zentalis Pharmaceuticals 10-K on SEC EDGAR · CIK 1725160 · Pharmaceutical Preparations

13F: who owns ZNTL and who is buying

Largest holders of ZNTL (13F)Largest holders of ZNTL (13F)5AM Venture Management, LLC$19.1MBlackRock$18.2MSquadron Capital Management LLC$17.9MTwo Sigma Investments, LP$14.7MVanguard Capital Management LLC$13.8MAcadian Asset Management LLC$13.0MCitadel Advisors LLC$11.1MRenaissance Technologies LLC$7.8MOpaleye Management$6.9MOrbimed Advisors LLC$6.7M
Funds' net buying of ZNTL by quarter (13F)Funds' net buying of ZNTL by quarter (13F)−$7.6M2024-09−$23.6M2024-12−$8.9M2025-03−$2.7M2025-06−$4.2M2025-09−$16.8M2025-12$6.3M2026-03$20.4M2026-06
Value of shares 13F filers added minus the value they sold, each quarter (quarters with most filings in).

More on ZNTL

History

Every quarter: Q4 2024 results

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