Filing Flows › Zymeworks (ZYME) › Q4 2025
Zymeworks (ZYME) Q4 2025 earnings results (fourth quarter 2025)
10-K filed Mar 2, 2026
Zymeworks (ZYME) reported revenue of $2.5M for the fourth quarter 2025 (Q4 2025), -92% from a year earlier and -91% from the quarter before.
Zymeworks, Q4 2025: revenue $2.5M (-92% year over year), net loss $41.2M, operating cash flow −$10.3M. The chart follows the revenue to costs, profit and cash.
| Q4 2025 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $2.5M | -91% | -92% |
| Operating profit | −$44.2M | — | — |
| Net earnings | −$41.2M | — | — |
| Operating cash flow | −$10.3M | — | — |
What changed
Revenue was $2.5M in Q4 2025, down 92% year over year and down 91% from the previous quarter.
Operating costs exceeded revenue by $44.2M, an operating margin of -1755.5%. Total costs fell 12% while revenue fell 92%. The quarter ended with a net loss of $41.2M, wider than the previous quarter's $19.6M loss.
Operating cash flow was −$10.3M. Non-cash charges added back $1.1M of depreciation and amortization and $8.8M of share-based compensation. Working capital and other items added $21.0M. Capital expenditures of $581K exceeded it, leaving free cash flow of −$10.8M.
Questions
What was Zymeworks' revenue in the fourth quarter 2025?
Zymeworks (ZYME) reported revenue of $2.5M for the fourth quarter 2025 (Q4 2025), -92% from a year earlier and -91% from the quarter before.
Source: Zymeworks 10-K on SEC EDGAR.