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Omeros vs Septerna: OMER and SEPN compared
Omeros is the larger company: $28.5M of revenue in its latest quarter (Q2 2026) against $26.7M for Septerna (Q2 2026). Omeros is more profitable, with an operating margin of 0.3% against -62.9%.
Where the money goes: OMER and SEPN
Omeros (OMER) · Q2 2026
Omeros, Q2 2026: revenue $28.5M, operating margin 0.3%, net earnings $13.2M, operating cash flow $4.1M. The chart follows the revenue to costs, profit and cash.
Septerna (SEPN) · Q2 2026
Septerna, Q2 2026: revenue $26.7M (225× year over year), operating margin -62.9%, net loss $13.0M, operating cash flow −$22.2M. The chart follows the revenue to costs, profit and cash.
| Omeros (OMER) | Septerna (SEPN) | |
|---|---|---|
| Latest quarter | Q2 2026 | Q2 2026 |
| Revenue | $28.5M | $26.7M |
| Revenue growth, Y/Y | — | 225× |
| Operating margin | 0.3% | -62.9% |
| Net earnings | $13.2M | −$13.0M |
| Net margin | 46.4% | -48.7% |
| Operating cash flow | $4.1M | −$22.2M |
| Free cash flow | $4.1M | — |
| Market value | $1.8B | — |
| P/E | 14.4× | — |
| Analysts’ mean target | $27.50 | — |
Questions
Which is bigger, Omeros or Septerna?
Omeros is the larger company: $28.5M of revenue in its latest quarter (Q2 2026) against $26.7M for Septerna (Q2 2026).
Is Omeros or Septerna growing faster?
Omeros is more profitable, with an operating margin of 0.3% against -62.9%.
More: Omeros earnings · how Omeros makes money · Septerna earnings · how Septerna makes money
From the companies' latest 10-Q, 10-K or earnings release (10-Q filed Aug 12, 2026; 10-Q filed Aug 10, 2026). Fiscal quarters can end on different dates. Not investment advice.