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Protagonist Therapeutics vs Harmony Biosciences Holdings: PTGX and HRMY compared
Protagonist Therapeutics is the larger company: $274M of revenue in its latest quarter (Q3 2026) against $269M for Harmony Biosciences Holdings (Q3 2026). Protagonist Therapeutics is growing faster (58× against +12% a year earlier). Protagonist Therapeutics is more profitable, with an operating margin of 79.6% against 20.2%.
Where the money goes: PTGX and HRMY
Protagonist Therapeutics (PTGX) · Q3 2026
Protagonist Therapeutics, Q3 2026: revenue $274M (58× year over year), operating margin 79.6%, net earnings $220M, operating cash flow −$23.2M. The chart follows the revenue to costs, profit and cash.
Harmony Biosciences Holdings (HRMY) · Q3 2026
Harmony Biosciences Holdings, Q3 2026: revenue $269M (+12% year over year), operating margin 20.2%, net earnings $48.2M, operating cash flow $76.7M. The chart follows the revenue to costs, profit and cash.
| Protagonist Therapeutics (PTGX) | Harmony Biosciences Holdings (HRMY) | |
|---|---|---|
| Latest quarter | Q3 2026 | Q3 2026 |
| Revenue | $274M | $269M |
| Revenue growth, Y/Y | 58× | +12% |
| Gross margin | — | 70.0% |
| Operating margin | 79.6% | 20.2% |
| Net earnings | $220M | $48.2M |
| Net margin | 80.2% | 17.9% |
| Operating cash flow | −$23.2M | $76.7M |
Questions
Which is bigger, Protagonist Therapeutics or Harmony Biosciences Holdings?
Protagonist Therapeutics is the larger company: $274M of revenue in its latest quarter (Q3 2026) against $269M for Harmony Biosciences Holdings (Q3 2026).
Is Protagonist Therapeutics or Harmony Biosciences Holdings growing faster?
Protagonist Therapeutics is growing faster (58× against +12% a year earlier).
Which is more profitable, Protagonist Therapeutics or Harmony Biosciences Holdings?
Protagonist Therapeutics is more profitable, with an operating margin of 79.6% against 20.2%.
More: Protagonist Therapeutics earnings · how Protagonist Therapeutics makes money · Harmony Biosciences Holdings earnings · how Harmony Biosciences Holdings makes money
From the companies' latest 10-Q, 10-K or earnings release (10-Q filed Nov 6, 2026; 10-Q filed Nov 4, 2026). Fiscal quarters can end on different dates. Not investment advice.