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Protagonist Therapeutics vs TG Therapeutics: PTGX and TGTX compared
Protagonist Therapeutics is the larger company: $274M of revenue in its latest quarter (Q3 2026) against $260M for TG Therapeutics (Q3 2026). Protagonist Therapeutics is growing faster (58× against +61% a year earlier). Protagonist Therapeutics is more profitable, with an operating margin of 79.6% against 33.0%.
Where the money goes: PTGX and TGTX
Protagonist Therapeutics (PTGX) · Q3 2026
Protagonist Therapeutics, Q3 2026: revenue $274M (58× year over year), operating margin 79.6%, net earnings $220M, operating cash flow −$23.2M. The chart follows the revenue to costs, profit and cash.
TG Therapeutics (TGTX) · Q3 2026
TG Therapeutics, Q3 2026: revenue $260M (+61% year over year), operating margin 33.0%, net earnings $55.5M. The chart follows the revenue to costs, profit and cash.
| Protagonist Therapeutics (PTGX) | TG Therapeutics (TGTX) | |
|---|---|---|
| Latest quarter | Q3 2026 | Q3 2026 |
| Revenue | $274M | $260M |
| Revenue growth, Y/Y | 58× | +61% |
| Operating margin | 79.6% | 33.0% |
| Net earnings | $220M | $55.5M |
| Net margin | 80.2% | 21.3% |
| Operating cash flow | −$23.2M | — |
| Market value | — | $8.7B |
| P/E | — | 19.7× |
| Analysts’ mean target | — | $69.71 |
Where the revenue comes from
TG Therapeutics
- Product revenue, net: $240M (92%)
- License, milestone, royalty and other revenue: $19.9M (8%)
Questions
Which is bigger, Protagonist Therapeutics or TG Therapeutics?
Protagonist Therapeutics is the larger company: $274M of revenue in its latest quarter (Q3 2026) against $260M for TG Therapeutics (Q3 2026).
Is Protagonist Therapeutics or TG Therapeutics growing faster?
Protagonist Therapeutics is growing faster (58× against +61% a year earlier).
Which is more profitable, Protagonist Therapeutics or TG Therapeutics?
Protagonist Therapeutics is more profitable, with an operating margin of 79.6% against 33.0%.
More: Protagonist Therapeutics earnings · how Protagonist Therapeutics makes money · TG Therapeutics earnings · how TG Therapeutics makes money
From the companies' latest 10-Q, 10-K or earnings release (10-Q filed Nov 6, 2026; 8-K filed Nov 9, 2026). Fiscal quarters can end on different dates. Not investment advice.