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Alnylam Pharmaceuticals (ALNY) Q4 2024 earnings results (fourth quarter 2024)

10-K filed Feb 13, 2025

Alnylam Pharmaceuticals (ALNY) reported revenue of $593M for the fourth quarter 2024 (Q4 2024), +35% from a year earlier and +18% from the quarter before. Operating margin was -17.7%, net loss $83.8M (14.1% of revenue).

Revenue$593M
Year over year+35%
Quarter over quarter+18%
Operating margin-17.7%
Net earnings−$83.8M

Alnylam Pharmaceuticals, Q4 2024: revenue $593M (+35% year over year), operating margin -17.7%, net loss $83.8M, operating cash flow −$94.7M. The chart follows the revenue to costs, profit and cash.

Q4 2024AmountQ/QY/Y
Revenue$593M+18%+35%
Operating profit−$105M——
Net earnings−$83.8M——
Operating cash flow−$94.7M——

What changed

Revenue was $593.2M in Q4 2024, up 35% year over year and up 18% from the previous quarter. AMVUTTRA was the largest line at 48% of revenue.

Operating costs exceeded revenue by $105.2M, an operating margin of -17.7%. Total costs grew 26% against revenue growth of 35%. The fastest-growing cost line was SG&A (+49%). The quarter ended with a net loss of $83.8M, narrower than the previous quarter's $111.6M loss. Net interest and other expense of $88.8M was the main reason.

Operating cash flow was −$94.7M. Non-cash charges added back $14.2M of depreciation and amortization and $91.6M of share-based compensation. Working capital and other items used $116.7M. Capital expenditures of $9.1M exceeded it, leaving free cash flow of −$103.8M.

Questions

What was Alnylam Pharmaceuticals' revenue in the fourth quarter 2024?

Alnylam Pharmaceuticals (ALNY) reported revenue of $593M for the fourth quarter 2024 (Q4 2024), +35% from a year earlier and +18% from the quarter before.

Was Alnylam Pharmaceuticals profitable in the fourth quarter 2024?

Operating loss was $105M (-17.7% of revenue) and net loss $83.8M.

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Source: Alnylam Pharmaceuticals 10-K on SEC EDGAR.