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Denali Therapeutics (DNLI) Q3 2026 earnings results (third quarter 2026)

10-Q filed Nov 3, 2026

Denali Therapeutics (DNLI) reported revenue of $17.8M for the third quarter 2026 (Q3 2026) and +393% from the quarter before. Operating margin was -713.0%, net earnings $70.1M (394.5% of revenue).

Revenue$17.8M
Year over year—
Quarter over quarter+393%
Operating margin-713.0%
Net earnings$70.1M

Denali Therapeutics, Q3 2026: revenue $17.8M, operating margin -713.0%, net earnings $70.1M, operating cash flow −$117M. The chart follows the revenue to costs, profit and cash.

Q3 2026AmountQ/QY/Y
Revenue$17.8M+393%—
Operating profit−$127M——
Net earnings$70.1M——
Operating cash flow−$117M——

What changed

Revenue was $17.8M in Q3 2026, up 393% from the previous quarter.

Operating costs exceeded revenue by $126.8M, an operating margin of -713.0%. Net earnings were $70.1M. The effective tax rate was 0.0%. Non-operating items added $196.9M, 281% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was −$117.4M. Non-cash charges added back $3.6M of depreciation and amortization and $22.9M of share-based compensation. Working capital and other items used $214.0M. Capital expenditures of $1.0M exceeded it, leaving free cash flow of −$118.5M.

Questions

What was Denali Therapeutics' revenue in the third quarter 2026?

Denali Therapeutics (DNLI) reported revenue of $17.8M for the third quarter 2026 (Q3 2026) and +393% from the quarter before.

Was Denali Therapeutics profitable in the third quarter 2026?

Operating loss was $127M (-713.0% of revenue) and net earnings $70.1M.

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Source: Denali Therapeutics 10-Q on SEC EDGAR.