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Ensysce Biosciences (ENSC) earnings and revenue breakdown

Latest: Q2 2026 · 10-Q filed Aug 13, 2026 · Ensysce Biosciences (ENSC) Q2 2026 earnings results →

Q2 2026 Revenue down 15% year over year to $1.2M · 221¢ of every $1 of revenue lost · operating margin -221.3%

Ensysce Biosciences made $1.2M in Q2 2026 (-15% Y/Y). Operating margin -221.3%, net loss $2.6M. See where every dollar goes — costs, profit and cash — as a Sankey from the 10-Q filed Aug 13, 2026.

Revenue$1.2M
Year over year-15%
Operating margin-221.3%
Net earnings−$2.6M
Operating cash flow−$2.0M

Drawing the Sankey…

Open the interactive Sankey → click any line for what the company wrote about it, compare Y/Y and Q/Q, export as PNG or PDF

What changed this quarter

Revenue was $1.2M in Q2 2026, down 15% year over year and up 21% from the previous quarter.

Operating costs exceeded revenue by $2.6M, an operating margin of -221.3%. Total costs grew 20% against a revenue fall of 15%. The fastest-growing cost line was Research & development (+29%). The quarter ended with a net loss of $2.6M, narrower than the previous quarter's $3.6M loss.

Operating cash flow was −$2.0M. Non-cash charges added back $7K of depreciation and $2K of share-based compensation. Working capital and other items added $600K.

Quarterly history

Ensysce Biosciences revenue by quarterEnsysce Biosciences revenue by quarter$1.3MQ4 2024$1.3MQ1 2025$1.4MQ2 2025$493KQ3 2025$1.9MQ4 2025$961KQ1 2026$1.2MQ2 2026
Ensysce Biosciences net earnings by quarterEnsysce Biosciences net earnings by quarter−$3.6MQ4 2024−$1.9MQ1 2025−$1.7MQ2 2025−$3.7MQ3 2025−$2.8MQ4 2025−$3.6MQ1 2026−$2.6MQ2 2026
QuarterFormFiledRevenueY/YOp. marginNet earningsOp. cash flow
Q2 202610-QAug 13, 2026$1.2M-15%-221.3%−$2.6M−$2.0M
Q1 202610-QMay 15, 2026$961K-27%-370.7%−$3.6M−$3.5M
Q4 202510-KMar 30, 2026$1.9M+44%-147.8%−$2.8M−$1.5M
Q3 202510-QNov 14, 2025$493K-86%-758.7%−$3.7M−$1.9M
Q2 202510-QAug 13, 2025$1.4M+654%-127.6%−$1.7M−$2.7M
Q1 202510-QMay 13, 2025$1.3M+332%-149.1%−$1.9M−$1.7M
Q4 202410-KMar 10, 2025$1.3M+153%-274.3%−$3.6M−$764K

Charts

Ensysce Biosciences: revenue growth, year over year and quarter over quarterEnsysce Biosciences: revenue growth, year over year and quarter over quarterY/YQ/Q+153%Q4 2024+332%+1%Q1 2025+400%+4%Q2 2025-86%-64%Q3 2025+44%+282%Q4 2025-27%-49%Q1 2026-15%+21%Q2 2026
Latest (Q2 2026): Y/Y -15%, Q/Q +21%.
Ensysce Biosciences: where the cash came from (+) and went (−), TTM to Q2 2026Ensysce Biosciences: where the cash came from (+) and went (−), TTM to Q2 2026Operating cash flow−$8.9MOther financing$7.4MCash drawn (+) / kept (−)$1.5MNot reconciled−$124K
From the cash-flow statement as filed (SEC XBRL). Cash is fungible: the bars do not say which dollar paid for what.
Ensysce Biosciences: profit against cash, quarter by quarterEnsysce Biosciences: profit against cash, quarter by quarterNet incomeOperating cash flow$662K−$1.0MQ3 2024−$3.6M−$764KQ4 2024−$1.9M−$1.7MQ1 2025−$1.7M−$2.7MQ2 2025−$3.7M−$1.9MQ3 2025−$2.8M−$1.5MQ4 2025−$3.6M−$3.5MQ1 2026−$2.6M−$2.0MQ2 2026
Latest (Q2 2026): Net income −$2.6M, Operating cash flow −$2.0M.
Ensysce Biosciences: diluted shares by fiscal year (split-adjusted)Ensysce Biosciences: diluted shares by fiscal year (split-adjusted)264MFY2020323MFY20213MFY20222MFY20233MFY20243MFY2025
-99.0% since FY2020: buybacks shrank the count; earlier years scaled for the 4-for-1 split before FY2025, 4-for-1 split before FY2024.
Ensysce Biosciences in its industry: growth against margin (225 companies, SIC 2834)Ensysce Biosciences in its industry: growth against margin (225 companies, SIC 2834)revenue growth, year over year →↑ operating marginmedian +11%median -50%JNJLLYMRKABBVPFEBMYABTREGNTEVAVTRSVRTXBHCZTSONCOGNALNYELANJAZZBMRNPRGOAMRXUTHRRPRXNRIXINSMKeenova Therapeutics plcALKSMDGLPAHCSRPTPTCTINDVBBIOACADCORTPBHANIPKNSAPTGXHRMYIONSAXSMTGTXSUPNTVTXCOLLVREOFAMPHMIRMPCRXRARELQDAARQTIRWDARDXNATRXNCREBSZLABXERSINVACRMDMNKDRYTMURGNPHATAUPHSNDXRIGLLGNDEOLSARWRPGENHROWVNDAOPKSDGRGERNETONAGIOPBYITNGXCYRXCYTKMRVIORGONUVBLFVNSIGAKROSAMRNZVRASPRYHRTXAKBABCYCKPTIGYREMGNXELTPSEPNVRDNLFCRCrinetics Pharmaceuticals, Inc.VSTMKURATBPHLABADCTNAMSFBIOXLODERMARCTRMTIAYTUFHTXENTATNXPOCULASMBWVEAPMDBFRIABEOSTOKLXRXCAPRIDYANKTRZOMDFINBPJANXSBFMGOSSETSTRCUSCPIXLIFDCUEAQSTPRAXWHWKVERUEMMAGENBVRCACELUQUREZYMEEQABCLIMNMKYNBAKTSRNACVSICNTBTRAWISCOEVFMTVRDLPCNCAMPAtaiBeckley Inc.CTMXALMSPMHSACRSVTGNROIVKRROJAGXKRSAABUSPRPHSTTKCPHITRDATXMDGOVXNWBOBIOEUPBIRDOVIDSPRBXBIOPRTAMCRBARVNMNOVSLNIGCBIOALGVNDNTHCPMDSPRORFLCOYASCYXBFRGSXTPBTAIQHCWBSERYARWRNACRGBPAVTXCLNNNTHIHINDAAGHALTONCOCRVOSKVIBOLTBDPTLYELIBOPULMENSC (-15%, -100%)
Pharmaceutical Preparations; dot size is quarterly revenue; dashed lines are the industry's medians.

Interactive views

The same charts as the app — open one to draw it.

💵Where each $1 goesinteractive

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🌏Named in Asian annual reportsinteractive

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🔄Rotation against the market and its industry (RRG)interactive

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🔍Earnings qualityinteractive

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⚖️Fair value by methodinteractive

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🔭Outlook & guidanceinteractive

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📈Investments: gains and what it boughtinteractive

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🏭Its industry’s money flow (input-output)interactive

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About Ensysce Biosciences

We were originally incorporated in the State of Delaware in April 2003 as PharmacoFore, Inc. and, in January 2012, we changed our name from PharmacoFore, Inc. to Signature Therapeutics Inc. (“ Signature ”). In December 2015, Signature merged with and into Ensysce Biosciences, Inc. (“ Former Ensysce ”). In June 2021, Former Ensysce merged with and into Leisure Acquisition Corporation (“ LACQ ”). As part of the transaction, LACQ changed its name to “Ensysce Biosciences, Inc.” The mailing address of our principal executive office is 7946 Ivanhoe Avenue, Suite 201, La Jolla, California 92037. Our corporate telephone number is (858) 263-4196. Our website address is www.ensysce.com. Information contained on our website, or connected thereto, does not constitute part of, and is not incorporated by reference into, this Annual Report on Form 10-K.

In its own words, from its 10-K, filed Mar 30, 2026.

Ensysce Biosciences against its Pharmaceutical Preparations peers

The largest companies of the same SEC industry, each at its latest quarter. Revenue growth: -15% against the peers' median +7%. Operating margin: -221.3% against the peers' median 20.4%.

CompanyQuarterRevenueY/YOp. margin
ENSC Ensysce BiosciencesQ2 2026$1.2M-15%-221.3%
JNJ Johnson & JohnsonQ3 2026$25.4B+6%0.1%
LLY ELI LillyQ3 2026$24.4B+39%34.5%
MRK MerckQ3 2026$18.1B+5%30.7%
ABBV AbbVieQ3 2026$17.4B+10%36.0%
PFE PfizerQ3 2026$16.6B-0.4%20.4%
BMY Bristol Myers SquibbQ3 2026$13.1B+7%19.4%
ABT Abbott LaboratoriesQ3 2026$13.0B+14%10.4%
REGN Regeneron PharmaceuticalsQ3 2026$5.1B+36%40.0%

Source: Ensysce Biosciences 10-Q on SEC EDGAR · CIK 1716947 · Pharmaceutical Preparations

13F: who owns ENSC and who is buying

Largest holders of ENSC (13F)Largest holders of ENSC (13F)Jane Street Group, LLC$61KStoneX Group$50KAdage Capital Partners GP, L.L.C.$43KVanguard Group$34KVirtu Financial LLC$28KPerceptive Advisors LLC$25KCitadel Advisors LLC$25KXTX Topco$22KGeode Capital Management, LLC$18KSusquehanna International Group, …$10K
Funds' net buying of ENSC by quarter (13F)Funds' net buying of ENSC by quarter (13F)$706K2024-12$478K2025-03−$388K2025-06$409K2025-09−$9K2025-12$18K2026-03−$20K2026-06
Value of shares 13F filers added minus the value they sold, each quarter (quarters with most filings in).

More on ENSC

History

Every quarter: Q2 2026 results · Q1 2026 results · Q4 2025 results · Q3 2025 results · Q2 2025 results · Q1 2025 results · Q4 2024 results

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