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Exelixis (EXEL) Q1 2026 earnings results (first quarter 2026)

10-Q filed May 5, 2026

Exelixis (EXEL) reported revenue of $611M for the first quarter 2026 (Q1 2026), +10% from a year earlier and +2% from the quarter before. Operating margin was 41.1%, net earnings $210M (34.5% of revenue).

Revenue$611M
Year over year+10%
Quarter over quarter+2%
Operating margin41.1%
Net earnings$210M

Exelixis, Q1 2026: revenue $611M (+10% year over year), operating margin 41.1%, net earnings $210M, operating cash flow $252M. The chart follows the revenue to costs, profit and cash.

Q1 2026AmountQ/QY/Y
Revenue$611M+2%+10%
Operating profit$251M+7%+35%
Net earnings$210M-14%+32%
Operating cash flow$252M-24%+19%
Free cash flow$250M-25%+20%

What changed

Revenue was $610.8M in Q1 2026, up 10% year over year and up 2% from the previous quarter. CABOMETYX was the largest line at 90% of revenue. CABOMETYX added $41.9M year over year (up 8%), 76% of the total change. COMETRIQ declined 9%.

Operating profit was $251.3M, a 41.1% margin (up 7.5 points year over year). Of the extra revenue versus Q1 2025, 116% reached operating profit, above the 34% margin then. Total costs fell 2% while revenue rose 10%. Net earnings were $210.5M, up 32% year over year. The effective tax rate was 21.4%.

Operating cash flow was $251.8M (up 19% year over year), 120% of net earnings. Non-cash charges added back $6.9M of depreciation and amortization and $29.1M of share-based compensation. Capital expenditures of $1.5M left free cash flow of $250.3M.

Questions

What was Exelixis' revenue in the first quarter 2026?

Exelixis (EXEL) reported revenue of $611M for the first quarter 2026 (Q1 2026), +10% from a year earlier and +2% from the quarter before.

Was Exelixis profitable in the first quarter 2026?

Operating profit was $251M (41.1% of revenue) and net earnings $210M.

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Source: Exelixis 10-Q on SEC EDGAR.