Filing Flows › Illumina (ILMN) › Q4 2025
Illumina (ILMN) Q4 2025 earnings results (fourth quarter 2025)
10-K filed Feb 12, 2026
Illumina (ILMN) reported revenue of $1.2B for the fourth quarter 2025 (Q4 2025), +5% from a year earlier and +7% from the quarter before. Operating margin was 17.3%, net earnings $334M (28.8% of revenue).
Illumina, Q4 2025: revenue $1.2B (+5% year over year), operating margin 17.3%, net earnings $334M, operating cash flow $321M. The chart follows the revenue to costs, profit and cash.
| Q4 2025 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $1.2B | +7% | +5% |
| Gross profit | $759M | +4% | +4% |
| Operating profit | $201M | -11% | +15% |
| Net earnings | $334M | +123% | +80% |
| Operating cash flow | $321M | +13% | -12% |
| Free cash flow | $267M | — | -17% |
What changed
Revenue was $1.2B in Q4 2025, up 5% year over year and up 7% from the previous quarter. Consumables was the largest line at 72% of revenue.
Gross margin was 65.5%, down 0.5 points from a year earlier. Operating profit was $0.20B, a 17.3% margin (up 1.5 points year over year). Of the extra revenue versus a year earlier, 47% reached operating profit, above the 16% margin then. Operating expenses grew 1% against revenue growth of 5%. The fastest-growing cost line was SG&A (+11%). Net earnings were $0.33B, up 80% year over year. The effective tax rate was 11.4%. Non-operating items added $0.18B, 47% of pre-tax earnings, so the bottom line overstates operating performance.
Operating cash flow was $0.32B (down 12% year over year), 96% of net earnings. Non-cash charges added back $0.07B of depreciation and amortization and $0.06B of share-based compensation. Working capital and other items used $0.14B. After purchases of property and equipment ($0.05B), free cash flow as the company reports it was $0.27B.
Questions
What was Illumina's revenue in the fourth quarter 2025?
Illumina (ILMN) reported revenue of $1.2B for the fourth quarter 2025 (Q4 2025), +5% from a year earlier and +7% from the quarter before.
Was Illumina profitable in the fourth quarter 2025?
Operating profit was $201M (17.3% of revenue) and net earnings $334M.
Source: Illumina 10-K on SEC EDGAR.