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Is Madrigal Pharmaceuticals (MDGL) a takeover target?

A leveraged buyout does not work for Madrigal Pharmaceuticals on its latest figures: it has no positive EBITDA to borrow against (−$151M over the last 12 months, on revenue of $1.4B). Historically 2.5% of companies with its figures were bought within a year (0.5× the average).

Share price$430.36
Market value$13.0B
Enterprise value$12.4B
Cash$961M
Debt$341M
Revenue, 12 months$1.4B
Revenue growth+93%
EBITDA, 12 months−$151M

Why a leveraged buyout does not fit

A leveraged buyout is paid for mostly with debt that the company's own cash flow repays. Madrigal Pharmaceuticals' EBITDA over the last 12 months was −$151M on revenue of $1.4B, so there is nothing to lend against and nothing to repay a loan with: a buyer would have to pay almost entirely with its own money. That is the kind of deal another company — a strategic buyer that wants the products, the pipeline or the technology — makes, not a private-equity fund. The model therefore gives no buyout price.

What a takeover could cost

Takeovers in its sector paid a median premium of 35% over the share price before the deal (the middle half 22% to 45%), according to the 15 merger proxies and tender-offer responses on EDGAR that state a premium. At the median, Madrigal Pharmaceuticals would cost about $580.99 a share, $17.6B for all its shares.

Premium%Price a shareAll shares
Low end (a quarter of deals paid less)22%$525.04$15.9B
Median35%$580.99$17.6B
High end (a quarter paid more)45%$624.02$18.9B

The odds, from history

Historically 2.5% of companies with its figures were bought within a year (0.5× the average). Its figures put it in decile 2 of 10 (10 = the most likely to be bought). The odds come from a model of every merger proxy, tender-offer response and going-private statement filed on EDGAR since 2011, set against each company's size, margins, debt, cash flow and growth the year before.

Madrigal Pharmaceuticals' latest quarter

Madrigal Pharmaceuticals, Q3 2026: revenue $431M (+50% year over year), operating margin 13.0%, net earnings $55.4M, operating cash flow $121M. The chart follows the revenue to costs, profit and cash.

Questions

Is Madrigal Pharmaceuticals being acquired?

No headline, 8-K or 13D about a sale is on file in the last year.

Could private equity buy Madrigal Pharmaceuticals?

A leveraged buyout does not work for Madrigal Pharmaceuticals on its latest figures: it has no positive EBITDA to borrow against (−$151M over the last 12 months, on revenue of $1.4B). With no cash flow to repay a loan, a buyer would pay almost entirely with its own money: a deal for another company (a strategic buyer), not for a private-equity fund.

What would a takeover of Madrigal Pharmaceuticals cost?

Takeovers in its sector paid a median premium of 35% over the share price before the deal (the middle half 22% to 45%), according to the 15 merger proxies and tender-offer responses on EDGAR that state a premium. At the median, Madrigal Pharmaceuticals would cost about $580.99 a share, $17.6B for all its shares.

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Updated Nov 8, 2026. Read automatically from SEC filings and public data; errors are possible. Not investment advice.