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Puma Biotechnology (PBYI) Q3 2025 earnings results (third quarter 2025)

10-Q filed Nov 6, 2025

Puma Biotechnology (PBYI) reported revenue of $54.5M for the third quarter 2025 (Q3 2025), -32% from a year earlier and +4% from the quarter before. Operating margin was 17.6%, net earnings $8.8M (16.2% of revenue).

Revenue$54.5M
Year over year-32%
Quarter over quarter+4%
Operating margin17.6%
Net earnings$8.8M

Puma Biotechnology, Q3 2025: revenue $54.5M (-32% year over year), operating margin 17.6%, net earnings $8.8M, operating cash flow $9.7M. The chart follows the revenue to costs, profit and cash.

Q3 2025AmountQ/QY/Y
Revenue$54.5M+4%-32%
Operating profit$9.6M+44%-57%
Net earnings$8.8M+51%-56%
Operating cash flow$9.7M-31%-12%
Free cash flow$9.7M-31%-12%

What changed

Revenue was $54.5M in Q3 2025, down 32% year over year and up 4% from the previous quarter. Product was the largest line at 95% of revenue. Royalty lost $21.8M year over year (down 89%), 84% of the total change.

Operating profit was $9.6M, a 17.6% margin (down 9.8 points year over year). Total costs fell 23% while revenue fell 32%. The fastest-growing cost line was Research & development (+27%). Net earnings were $8.8M, down 56% year over year. The effective tax rate was 4.3%.

Operating cash flow was $9.7M (down 12% year over year), 110% of net earnings. Non-cash charges added back $2.7M of depreciation and amortization and $1.7M of share-based compensation. Working capital and other items used $3.5M. Capital expenditures of $26K left free cash flow of $9.7M.

Questions

What was Puma Biotechnology's revenue in the third quarter 2025?

Puma Biotechnology (PBYI) reported revenue of $54.5M for the third quarter 2025 (Q3 2025), -32% from a year earlier and +4% from the quarter before.

Was Puma Biotechnology profitable in the third quarter 2025?

Operating profit was $9.6M (17.6% of revenue) and net earnings $8.8M.

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Source: Puma Biotechnology 10-Q on SEC EDGAR.