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Schrodinger (SDGR) Q3 2025 earnings results (third quarter 2025)

10-Q filed Nov 5, 2025

Schrodinger (SDGR) reported revenue of $54.3M for the third quarter 2025 (Q3 2025), +54% from a year earlier and -0.8% from the quarter before. Operating margin was -84.6%, net loss $32.8M (60.4% of revenue).

Revenue$54.3M
Year over year+54%
Quarter over quarter-0.8%
Operating margin-84.6%
Net earnings−$32.8M

Schrodinger, Q3 2025: revenue $54.3M (+54% year over year), operating margin -84.6%, net loss $32.8M, operating cash flow −$61.9M. The chart follows the revenue to costs, profit and cash.

Q3 2025AmountQ/QY/Y
Revenue$54.3M-0.8%+54%
Operating profit−$45.9M——
Net earnings−$32.8M——
Operating cash flow−$61.9M——

What changed

Revenue was $54.3M in Q3 2025, up 54% year over year and down 1% from the previous quarter. Revenue from contracts with customers was the largest line at 66% of revenue. Revenue from contracts with customers added $7.2M year over year (up 25%), 38% of the total change.

Gross margin was 51.6%, up 1.4 points from a year earlier. Operating costs exceeded revenue by $45.9M, an operating margin of -84.6%. Operating expenses fell 14% while revenue rose 54%. The quarter ended with a net loss of $32.8M, narrower than the previous quarter's $43.2M loss. Non-operating items added $13.3M, -41% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was −$61.9M. Non-cash charges added back $1.5M of depreciation and amortization and $10.8M of share-based compensation. Working capital and other items used $41.4M. Capital expenditures of $491K exceeded it, leaving free cash flow of −$62.4M.

Questions

What was Schrodinger's revenue in the third quarter 2025?

Schrodinger (SDGR) reported revenue of $54.3M for the third quarter 2025 (Q3 2025), +54% from a year earlier and -0.8% from the quarter before.

Was Schrodinger profitable in the third quarter 2025?

Operating loss was $45.9M (-84.6% of revenue) and net loss $32.8M.

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Source: Schrodinger 10-Q on SEC EDGAR.