Filing Flows › Schrodinger (SDGR) › Q4 2025
Schrodinger (SDGR) Q4 2025 earnings results (fourth quarter 2025)
10-K filed Feb 25, 2026
Schrodinger (SDGR) reported revenue of $87.2M for the fourth quarter 2025 (Q4 2025), -1% from a year earlier and +61% from the quarter before. Operating margin was -19.7%, net earnings $32.5M (37.3% of revenue).
Schrodinger, Q4 2025: revenue $87.2M (-1% year over year), operating margin -19.7%, net earnings $32.5M, operating cash flow −$16.1M. The chart follows the revenue to costs, profit and cash.
| Q4 2025 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $87.2M | +61% | -1% |
| Operating profit | −$17.2M | — | — |
| Net earnings | $32.5M | — | — |
| Operating cash flow | −$16.1M | — | — |
What changed
Revenue was $87.2M in Q4 2025, down 1% year over year and up 61% from the previous quarter. Software products and services was the largest line at 79% of revenue.
Gross margin was 65.7%, down 6.9 points from a year earlier. Operating costs exceeded revenue by $17.2M, an operating margin of -19.7%. Operating expenses fell 12% while revenue fell 1%. Net earnings were $32.5M. The effective tax rate was 1.4%. Non-operating items added $50.1M, 152% of pre-tax earnings, so the bottom line overstates operating performance.
Operating cash flow was −$16.1M. Non-cash charges added back $1.4M of depreciation and amortization and $9.9M of share-based compensation. Working capital and other items used $60.0M. Capital expenditures of $41K exceeded it, leaving free cash flow of −$16.1M.
Questions
What was Schrodinger's revenue in the fourth quarter 2025?
Schrodinger (SDGR) reported revenue of $87.2M for the fourth quarter 2025 (Q4 2025), -1% from a year earlier and +61% from the quarter before.
Was Schrodinger profitable in the fourth quarter 2025?
Operating loss was $17.2M (-19.7% of revenue) and net earnings $32.5M.
Source: Schrodinger 10-K on SEC EDGAR.