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Septerna (SEPN) Q4 2024 earnings results (fourth quarter 2024)

10-K filed Mar 27, 2025

Septerna (SEPN) reported revenue of $212K for the fourth quarter 2024 (Q4 2024), +80% from a year earlier and +20% from the quarter before.

Revenue$212K
Year over year+80%
Quarter over quarter+20%
Operating margin—
Net earnings−$20.7M

Septerna, Q4 2024: revenue $212K (+80% year over year), net loss $20.7M, operating cash flow −$21.0M. The chart follows the revenue to costs, profit and cash.

Q4 2024AmountQ/QY/Y
Revenue$212K+20%+80%
Operating profit−$24.7M——
Net earnings−$20.7M——
Operating cash flow−$21.0M——

What changed

Revenue was $212K in Q4 2024, up 80% year over year and up 20% from the previous quarter.

Operating costs exceeded revenue by $24.7M, an operating margin of -11659.4%. The quarter ended with a net loss of $20.7M, wider than the previous quarter's $20.5M loss.

Operating cash flow was −$21.0M. Non-cash charges added back $388K of depreciation and amortization and $1.3M of share-based compensation. Working capital and other items used $1.9M. Capital expenditures of $612K exceeded it, leaving free cash flow of −$21.6M.

Questions

What was Septerna's revenue in the fourth quarter 2024?

Septerna (SEPN) reported revenue of $212K for the fourth quarter 2024 (Q4 2024), +80% from a year earlier and +20% from the quarter before.

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Source: Septerna 10-K on SEC EDGAR.