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Who owns Septerna (SEPN) stock

149 funds reported Septerna (SEPN) shares in their latest 13F filings, worth $1.6B in all. The largest holder is RA Capital Management, L.P. ($234M). Last quarter 81 funds added to their stakes and 48 cut them.

Largest holders of SEPN (13F)Largest holders of SEPN (13F)RA Capital Management, L.P.$234MTRV GP V, LLC$208MDriehaus Capital Management LLC$148MTRV GP VI, LLC$141MSamsara BioCapital, LLC$105MGoldman Sachs Group$103MBlackRock$64.7MSiren, L.L.C.$63.6MAvoro Capital Advisors LLC$44.8MJupiter Topco LLC$43.7M

Largest holders (13F)

FundSharesValueChangeQuarter
RA Capital Management, L.P.6,995,858$234Munchanged2026-06-30
TRV GP V, LLC6,215,591$208Munchanged2026-06-30
Driehaus Capital Management LLC4,433,058$148Mincrease2026-06-30
TRV GP VI, LLC4,211,659$141Munchanged2026-06-30
Samsara BioCapital, LLC3,149,128$105Munchanged2026-06-30
Goldman Sachs Group3,062,766$103Mincrease2026-06-30
BlackRock1,932,088$64.7Mincrease2026-06-30
Siren, L.L.C.1,900,000$63.6Mdecrease2026-06-30
Avoro Capital Advisors LLC1,337,500$44.8Munchanged2026-06-30
Jupiter Topco LLC1,307,500$43.7Mbase2026-06-30
Vanguard Group1,508,195$42.0Mdecrease2025-12-31
Vanguard Capital Management LLC1,221,673$40.9Mincrease2026-06-30
Primecap Management1,167,382$39.1Mincrease2026-06-30
First Light Asset Management, LLC963,260$32.3Mincrease2026-06-30
ADAR1 Capital Management, LLC940,747$31.5Mdecrease2026-06-30

Septerna's latest quarter

Septerna, Q2 2026: revenue $26.7M (225× year over year), operating margin -62.9%, net loss $13.0M, operating cash flow −$22.2M. The chart follows the revenue to costs, profit and cash.

Questions

Who owns the most SEPN stock?

By the latest 13F filings: RA Capital Management, L.P. ($234M); TRV GP V, LLC ($208M); Driehaus Capital Management LLC ($148M); TRV GP VI, LLC ($141M); Samsara BioCapital, LLC ($105M).

What is the short interest in SEPN?

3,522,956 shares were sold short at the 2026-10-15 settlement, 13.78% of the float.

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Updated Nov 8, 2026. Read automatically from SEC filings and public data; errors are possible. Not investment advice.