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Spero Therapeutics (SPRO) Q1 2026 earnings results (first quarter 2026)

10-Q filed May 13, 2026

Spero Therapeutics (SPRO) reported revenue of $258K for the first quarter 2026 (Q1 2026), -96% from a year earlier and -99% from the quarter before.

Revenue$258K
Year over year-96%
Quarter over quarter-99%
Operating margin—
Net earnings−$7.2M

Spero Therapeutics, Q1 2026: revenue $258K (-96% year over year), net loss $7.2M, operating cash flow $15.9M. The chart follows the revenue to costs, profit and cash.

Q1 2026AmountQ/QY/Y
Revenue$258K-99%-96%
Operating profit−$7.5M-124%—
Net earnings−$7.2M-123%—
Operating cash flow$15.9M——

What changed

Revenue was $258K in Q1 2026, down 96% year over year and down 99% from the previous quarter.

Operating costs exceeded revenue by $7.5M, an operating margin of -2921.7%. Total costs fell 62% while revenue fell 96%. The quarter ended with a net loss of $7.2M, after a profit of $31.5M the previous quarter.

Operating cash flow was $15.9M. Non-cash charges added back $1.1M of share-based compensation. Working capital and other items added $22.0M.

Questions

What was Spero Therapeutics' revenue in the first quarter 2026?

Spero Therapeutics (SPRO) reported revenue of $258K for the first quarter 2026 (Q1 2026), -96% from a year earlier and -99% from the quarter before.

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Source: Spero Therapeutics 10-Q on SEC EDGAR.