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How Spero Therapeutics (SPRO) makes money

Spero Therapeutics (SPRO) made $258K of revenue in the first quarter 2026 (Q1 2026), -96% from a year earlier.

Drawing the Sankey…

Spero Therapeutics: revenue by line, Q1 2025 to Q4 2025Spero Therapeutics: revenue by line, Q1 2025 to Q4 2025Collaboration Revenue…Collaboration RevenueGrant RevenueCollaboration Revenue Related Party: $27.1M latest$27.1MCollaboration Revenue: $12.6M latest$12.6MGrant Revenue: $1.6M latestQ1 2025Q2 2025Q3 2025Q4 2025
Collaboration Revenue went from 0% of revenue in Q1 2025 to 30% in Q4 2025, the largest shift in the mix.
Spero Therapeutics revenue by quarterSpero Therapeutics revenue by quarter$15.0MQ4 2024$5.9MQ1 2025$14.2MQ2 2025$5.4MQ3 2025$41.3MQ4 2025$258KQ1 2026

Where each dollar of revenue goes

LineQ1 2026% of revenue
Revenue$258K100.0%
Operating cash flow$15.9Mn/m

Revenue, quarter by quarter

QuarterRevenueY/Y
Q1 2026$258K-96%
Q4 2025$41.3M+174%
Q3 2025$5.4M-60%
Q2 2025$14.2M+39%
Q1 2025$5.9M-37%
Q4 2024$15.0M-80%

From Spero Therapeutics' 10-Q filed May 13, 2026 (on EDGAR).

Questions

How does Spero Therapeutics make money?

Spero Therapeutics (SPRO) made $258K of revenue in the first quarter 2026 (Q1 2026), -96% from a year earlier.

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Updated Nov 8, 2026. Read automatically from SEC filings and public data; errors are possible. Not investment advice.