Filing Flows › Upstream Bio (UPB) › Who owns the stock
Who owns Upstream Bio (UPB) stock
137 funds reported Upstream Bio (UPB) shares in their latest 13F filings, worth $377M in all. The largest holder is Vanguard Group ($64.8M). Last quarter 88 funds added to their stakes and 54 cut them.
Largest holders (13F)
| Fund | Shares | Value | Change | Quarter |
|---|---|---|---|---|
| Vanguard Group | 2,388,439 | $64.8M | decrease | 2025-12-31 |
| FMR LLC | 8,162,897 | $56.5M | increase | 2026-06-30 |
| Orbimed Advisors LLC | 5,693,589 | $39.4M | unchanged | 2026-06-30 |
| BlackRock | 3,753,358 | $26.0M | increase | 2026-06-30 |
| Decheng Capital LLC | 2,724,868 | $18.9M | unchanged | 2026-06-30 |
| Enavate Sciences GP, LLC | 2,459,703 | $17.0M | unchanged | 2026-06-30 |
| Vanguard Capital Management LLC | 1,876,734 | $13.0M | increase | 2026-06-30 |
| Millennium Management LLC | 1,143,775 | $7.9M | increase | 2026-06-30 |
| D. E. Shaw | 1,036,044 | $7.2M | increase | 2026-06-30 |
| Qube Research & Technologies | 978,500 | $6.8M | increase | 2026-06-30 |
| Parkman Healthcare Partners LLC | 935,247 | $6.5M | increase | 2026-06-30 |
| Geode Capital Management, LLC | 931,261 | $6.4M | decrease | 2026-06-30 |
| SEB Asset Management AB | 878,473 | $6.1M | unchanged | 2026-06-30 |
| Woodline Partners LP | 831,481 | $5.8M | unchanged | 2026-06-30 |
| State Street | 766,323 | $5.3M | increase | 2026-06-30 |
Upstream Bio's latest quarter
Upstream Bio, Q2 2026: revenue $773K (-18% year over year), net loss $39.7M, operating cash flow −$35.6M. The chart follows the revenue to costs, profit and cash.
Questions
Who owns the most UPB stock?
By the latest 13F filings: Vanguard Group ($64.8M); FMR LLC ($56.5M); Orbimed Advisors LLC ($39.4M); BlackRock ($26.0M); Decheng Capital LLC ($18.9M).
What is the short interest in UPB?
4,480,785 shares were sold short at the 2026-10-15 settlement, -0.75% of the float.
Updated Nov 8, 2026. Read automatically from SEC filings and public data; errors are possible. Not investment advice.