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Xencor (XNCR) Q1 2025 earnings results (first quarter 2025)

10-Q filed May 7, 2025

Xencor (XNCR) reported revenue of $32.7M for the first quarter 2025 (Q1 2025), +105% from a year earlier and -38% from the quarter before. Operating margin was -131.9%, net loss $48.6M (148.6% of revenue).

Revenue$32.7M
Year over year+105%
Quarter over quarter-38%
Operating margin-131.9%
Net earnings−$48.6M

Xencor, Q1 2025: revenue $32.7M (+105% year over year), operating margin -131.9%, net loss $48.6M, operating cash flow −$16.2M. The chart follows the revenue to costs, profit and cash.

Q1 2025AmountQ/QY/Y
Revenue$32.7M-38%+105%
Operating profit−$43.2M——
Net earnings−$48.6M——
Operating cash flow−$16.2M——

What changed

Revenue was $32.7M in Q1 2025, up 105% year over year and down 38% from the previous quarter. Royalties was the largest line at 56% of revenue. Milestone added $14.0M year over year (up 2800%), 84% of the total change.

Operating costs exceeded revenue by $43.2M, an operating margin of -131.9%. Total costs grew 7% against revenue growth of 105%. The fastest-growing cost line was General & admin (+26%). The quarter ended with a net loss of $48.6M, wider than the previous quarter's $46.2M loss. Minority interests bore $214K of it: to shareholders the quarter was a loss of $48.4M.

Operating cash flow was −$16.2M. Non-cash charges added back $2.7M of depreciation and amortization and $12.2M of share-based compensation. Working capital and other items added $17.5M. Capital expenditures of $1.4M exceeded it, leaving free cash flow of −$17.7M.

Questions

What was Xencor's revenue in the first quarter 2025?

Xencor (XNCR) reported revenue of $32.7M for the first quarter 2025 (Q1 2025), +105% from a year earlier and -38% from the quarter before.

Was Xencor profitable in the first quarter 2025?

Operating loss was $43.2M (-131.9% of revenue) and net loss $48.6M.

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Source: Xencor 10-Q on SEC EDGAR.