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Xencor (XNCR) Q3 2025 earnings results (third quarter 2025)

10-Q filed Nov 5, 2025

Xencor (XNCR) reported revenue of $21.0M for the third quarter 2025 (Q3 2025), +18% from a year earlier and -52% from the quarter before. Operating margin was -226.3%, net loss $6.0M (28.7% of revenue).

Revenue$21.0M
Year over year+18%
Quarter over quarter-52%
Operating margin-226.3%
Net earnings−$6.0M

Xencor, Q3 2025: revenue $21.0M (+18% year over year), operating margin -226.3%, net loss $6.0M, operating cash flow −$30.8M. The chart follows the revenue to costs, profit and cash.

Q3 2025AmountQ/QY/Y
Revenue$21.0M-52%+18%
Operating profit−$47.5M——
Net earnings−$6.0M——
Operating cash flow−$30.8M——

What changed

Revenue was $21.0M in Q3 2025, up 18% year over year and down 52% from the previous quarter.

Operating costs exceeded revenue by $47.5M, an operating margin of -226.3%. Total costs fell 6% while revenue rose 18%. The quarter ended with a net loss of $6.0M, narrower than the previous quarter's $30.8M loss. Non-operating items added $41.5M, -688% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was −$30.8M. Non-cash charges added back $2.6M of depreciation and amortization and $10.1M of share-based compensation. Working capital and other items used $37.5M. Capital expenditures of $183K exceeded it, leaving free cash flow of −$31.0M.

Questions

What was Xencor's revenue in the third quarter 2025?

Xencor (XNCR) reported revenue of $21.0M for the third quarter 2025 (Q3 2025), +18% from a year earlier and -52% from the quarter before.

Was Xencor profitable in the third quarter 2025?

Operating loss was $47.5M (-226.3% of revenue) and net loss $6.0M.

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Source: Xencor 10-Q on SEC EDGAR.