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Avalo Therapeutics (AVTX) earnings and revenue breakdown
Latest: Q4 2025 · 10-K filed Mar 23, 2026 · Avalo Therapeutics (AVTX) Q4 2025 earnings results →
Q4 2025 Revenue down 69% year over year to $59K
Avalo Therapeutics made $59K in Q4 2025 (-69% Y/Y). Operating margin n/m, net loss $13.7M. See where every dollar goes — costs, profit and cash — as a Sankey from the 10-K filed Mar 23, 2026.
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What changed this quarter
Revenue was $59K in Q4 2025, down 69% year over year.
Operating costs exceeded revenue by $19.7M, an operating margin of -33461.0%. Total costs grew 47% against a revenue fall of 69%. The fastest-growing cost line was Research & development (+62%). The quarter ended with a net loss of $13.7M. Non-operating items added $6.2M, -45% of pre-tax earnings, so the bottom line overstates operating performance.
Operating cash flow was −$14.2M. Non-cash charges added back $16K of depreciation and amortization and $4.5M of share-based compensation. Working capital and other items used $5.0M.
Quarterly history
| Quarter | Form | Filed | Revenue | Y/Y | Op. margin | Net earnings | Op. cash flow |
|---|---|---|---|---|---|---|---|
| Q4 2025 | 10-K | Mar 23, 2026 | $59K | -69% | n/m | −$13.7M | −$14.2M |
| Q4 2024 | 10-K | Mar 20, 2025 | $192K | -66% | n/m | −$35.3M | −$15.0M |
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About Avalo Therapeutics
We are a clinical stage biotechnology company fully dedicated to developing IL-1β-based treatments for immune-mediated inflammatory diseases. Our lead product candidate, abdakibart (AVTX-009), an anti-IL-1β monoclonal antibody (“mAb”) is in a Phase 2 clinical trial for hidradenitis suppurativa (“HS”). We are also exploring additional opportunities to make an impact in prevalent indications that have significant remaining unmet needs. Our current focus is on completing the Phase 2 (“LOTUS”) trial evaluating abdakibart (AVTX-009) in HS, preparing for the anticipated topline data readout in the second quarter of 2026, and planning for our Phase 3 trial(s).
In its own words, from its 10-K, filed Mar 23, 2026.
Avalo Therapeutics against its Pharmaceutical Preparations peers
The largest companies of the same SEC industry, each at its latest quarter. Revenue growth: -69% against the peers' median +7%.
| Company | Quarter | Revenue | Y/Y | Op. margin |
|---|---|---|---|---|
| AVTX Avalo Therapeutics | Q4 2025 | $59K | -69% | n/m |
| JNJ Johnson & Johnson | Q3 2026 | $25.4B | +6% | 0.1% |
| LLY ELI Lilly | Q3 2026 | $24.4B | +39% | 34.5% |
| MRK Merck | Q3 2026 | $18.1B | +5% | 30.7% |
| ABBV AbbVie | Q3 2026 | $17.4B | +10% | 36.0% |
| PFE Pfizer | Q3 2026 | $16.6B | -0.4% | 20.4% |
| BMY Bristol Myers Squibb | Q3 2026 | $13.1B | +7% | 19.4% |
| ABT Abbott Laboratories | Q3 2026 | $13.0B | +14% | 10.4% |
| REGN Regeneron Pharmaceuticals | Q3 2026 | $5.1B | +36% | 40.0% |
Source: Avalo Therapeutics 10-K on SEC EDGAR · CIK 1534120 · Pharmaceutical Preparations
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History
Every quarter: Q4 2025 results · Q4 2024 results