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Avalo Therapeutics (AVTX) earnings and revenue breakdown

Latest: Q4 2025 · 10-K filed Mar 23, 2026 · Avalo Therapeutics (AVTX) Q4 2025 earnings results →

Q4 2025 Revenue down 69% year over year to $59K

Avalo Therapeutics made $59K in Q4 2025 (-69% Y/Y). Operating margin n/m, net loss $13.7M. See where every dollar goes — costs, profit and cash — as a Sankey from the 10-K filed Mar 23, 2026.

Revenue$59K
Year over year-69%
Operating marginn/m
Net earnings−$13.7M
Operating cash flow−$14.2M

Drawing the Sankey…

Open the interactive Sankey → click any line for what the company wrote about it, compare Y/Y and Q/Q, export as PNG or PDF

What changed this quarter

Revenue was $59K in Q4 2025, down 69% year over year.

Operating costs exceeded revenue by $19.7M, an operating margin of -33461.0%. Total costs grew 47% against a revenue fall of 69%. The fastest-growing cost line was Research & development (+62%). The quarter ended with a net loss of $13.7M. Non-operating items added $6.2M, -45% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was −$14.2M. Non-cash charges added back $16K of depreciation and amortization and $4.5M of share-based compensation. Working capital and other items used $5.0M.

Quarterly history

Avalo Therapeutics revenue by quarterAvalo Therapeutics revenue by quarter$192KQ4 2024$59KQ4 2025
Avalo Therapeutics net earnings by quarterAvalo Therapeutics net earnings by quarter−$35.3MQ4 2024−$13.7MQ4 2025
QuarterFormFiledRevenueY/YOp. marginNet earningsOp. cash flow
Q4 202510-KMar 23, 2026$59K-69%n/m−$13.7M−$14.2M
Q4 202410-KMar 20, 2025$192K-66%n/m−$35.3M−$15.0M

Charts

Avalo Therapeutics: where the cash came from (+) and went (−), TTM to Q3 2026Avalo Therapeutics: where the cash came from (+) and went (−), TTM to Q3 2026Other financing$405MOther investing−$313MOperating cash flow−$63.5MCash drawn (+) / kept (−)−$38.1MShares issued$10.7MTaxes on employees’ shares−$779K
From the cash-flow statement as filed (SEC XBRL). Cash is fungible: the bars do not say which dollar paid for what.
Avalo Therapeutics: profit against cash, quarter by quarterAvalo Therapeutics: profit against cash, quarter by quarterNet incomeOperating cash flow−$35.3M−$15.0MQ4 2024−$13.1M−$9.5MQ1 2025−$20.8M−$11.4MQ2 2025−$30.6M−$16.4MQ3 2025−$13.7M−$14.2MQ4 2025−$19.6M−$17.7MQ1 2026−$36.4M−$20.0MQ2 2026−$18.9M−$11.5MQ3 2026
Latest (Q3 2026): Net income −$18.9M, Operating cash flow −$11.5M.
Avalo Therapeutics: diluted shares by fiscal year (split-adjusted)Avalo Therapeutics: diluted shares by fiscal year (split-adjusted)0MFY20221MFY202315MFY202413MFY2025
+16997.1% since FY2022: more shares outstanding (issuance, stock pay); earlier years scaled for the 2-for-1 split before FY2025.
Avalo Therapeutics in its industry: growth against margin (225 companies, SIC 2834)Avalo Therapeutics in its industry: growth against margin (225 companies, SIC 2834)revenue growth, year over year →↑ operating marginmedian +11%median -50%JNJLLYMRKABBVPFEBMYABTREGNTEVAVTRSVRTXBHCZTSONCOGNALNYELANJAZZBMRNPRGOAMRXUTHRRPRXNRIXINSMKeenova Therapeutics plcALKSMDGLPAHCSRPTPTCTINDVBBIOACADCORTPBHANIPKNSAPTGXHRMYIONSAXSMTGTXSUPNTVTXCOLLVREOFAMPHMIRMPCRXRARELQDAARQTIRWDARDXNATRXNCREBSZLABXERSINVACRMDMNKDRYTMURGNPHATAUPHSNDXRIGLLGNDEOLSARWRPGENHROWVNDAOPKSDGRGERNETONAGIOPBYITNGXCYRXCYTKMRVIORGONUVBLFVNSIGAKROSAMRNZVRASPRYHRTXAKBABCYCKPTIGYREMGNXELTPSEPNVRDNLFCRCrinetics Pharmaceuticals, Inc.VSTMKURATBPHLABADCTNAMSFBIOXLODERMARCTRMTIAYTUFHTXENTATNXPOCULASMBWVEAPMDBFRIABEOSTOKLXRXCAPRIDYANKTRZOMDFINBPJANXSBFMGOSSETSTRCUSCPIXLIFDCUEAQSTPRAXWHWKVERUEMMAGENBVRCACELUQUREZYMEEQABCLIMNMKYNBAKTSRNACVSICNTBTRAWISCOEVFMTVRDLPCNCAMPAtaiBeckley Inc.CTMXALMSPMHSACRSVTGNROIVKRROJAGXENSCKRSAABUSPRPHSTTKCPHITRDATXMDGOVXNWBOBIOEUPBIRDOVIDSPRBXBIOPRTAMCRBARVNMNOVSLNIGCBIOALGVNDNTHCPMDSPRORFLCOYASCYXBFRGSXTPBTAIQHCWBSERYARWRNACRGBPCLNNNTHIHINDAAGHALTONCOCRVOSKVIBOLTBDPTLYELIBOPULMAVTX (-69%, -100%)
Pharmaceutical Preparations; dot size is quarterly revenue; dashed lines are the industry's medians.

Interactive views

The same charts as the app — open one to draw it.

💵Where each $1 goesinteractive

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🌏Named in Asian annual reportsinteractive

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🔄Rotation against the market and its industry (RRG)interactive

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🔍Earnings qualityinteractive

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⚖️Fair value by methodinteractive

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🔭Outlook & guidanceinteractive

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📈Investments: gains and what it boughtinteractive

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🏭Its industry’s money flow (input-output)interactive

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About Avalo Therapeutics

We are a clinical stage biotechnology company fully dedicated to developing IL-1β-based treatments for immune-mediated inflammatory diseases. Our lead product candidate, abdakibart (AVTX-009), an anti-IL-1β monoclonal antibody (“mAb”) is in a Phase 2 clinical trial for hidradenitis suppurativa (“HS”). We are also exploring additional opportunities to make an impact in prevalent indications that have significant remaining unmet needs. Our current focus is on completing the Phase 2 (“LOTUS”) trial evaluating abdakibart (AVTX-009) in HS, preparing for the anticipated topline data readout in the second quarter of 2026, and planning for our Phase 3 trial(s).

In its own words, from its 10-K, filed Mar 23, 2026.

Avalo Therapeutics against its Pharmaceutical Preparations peers

The largest companies of the same SEC industry, each at its latest quarter. Revenue growth: -69% against the peers' median +7%.

CompanyQuarterRevenueY/YOp. margin
AVTX Avalo TherapeuticsQ4 2025$59K-69%n/m
JNJ Johnson & JohnsonQ3 2026$25.4B+6%0.1%
LLY ELI LillyQ3 2026$24.4B+39%34.5%
MRK MerckQ3 2026$18.1B+5%30.7%
ABBV AbbVieQ3 2026$17.4B+10%36.0%
PFE PfizerQ3 2026$16.6B-0.4%20.4%
BMY Bristol Myers SquibbQ3 2026$13.1B+7%19.4%
ABT Abbott LaboratoriesQ3 2026$13.0B+14%10.4%
REGN Regeneron PharmaceuticalsQ3 2026$5.1B+36%40.0%

Source: Avalo Therapeutics 10-K on SEC EDGAR · CIK 1534120 · Pharmaceutical Preparations

13F: who owns AVTX and who is buying

Largest holders of AVTX (13F)Largest holders of AVTX (13F)FMR LLC$94.3MBlackRock$80.7MNantahala Capital Management, LLC$68.8MDeep Track Capital, LP$66.7MCaligan Partners LP$58.5MTCG Crossover Management, LLC$55.8MAffinity Asset Advisors, LLC$53.6MState Street$53.4MPoint72 Asset Management, L.P.$44.1MAvoro Capital Advisors LLC$43.1M
Funds' net buying of AVTX by quarter (13F)Funds' net buying of AVTX by quarter (13F)$54.2M2024-09$344K2024-12$6.0M2025-03−$2.0M2025-06$93.9M2025-09$26.2M2025-12$152M2026-03$157M2026-06
Value of shares 13F filers added minus the value they sold, each quarter (quarters with most filings in).

More on AVTX

History

Every quarter: Q4 2025 results · Q4 2024 results

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