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Axsome Therapeutics (AXSM) Q2 2025 earnings results (second quarter 2025)

10-Q filed Aug 4, 2025

Axsome Therapeutics (AXSM) reported revenue of $150M for the second quarter 2025 (Q2 2025), +72% from a year earlier and +24% from the quarter before. Operating margin was -24.5%, net loss $48.0M (32.0% of revenue).

Revenue$150M
Year over year+72%
Quarter over quarter+24%
Operating margin-24.5%
Net earnings−$48.0M

Axsome Therapeutics, Q2 2025: revenue $150M (+72% year over year), operating margin -24.5%, net loss $48.0M, operating cash flow −$32.4M. The chart follows the revenue to costs, profit and cash.

Q2 2025AmountQ/QY/Y
Revenue$150M+24%+72%
Operating profit−$36.7M——
Net earnings−$48.0M——
Operating cash flow−$32.4M——

What changed

Revenue was $150.0M in Q2 2025, up 72% year over year and up 24% from the previous quarter. Product was the largest line at 99% of revenue. Product added $62.4M year over year (up 72%), 99% of the total change.

Operating costs exceeded revenue by $36.7M, an operating margin of -24.5%. Total costs grew 13% against revenue growth of 72%. The quarter ended with a net loss of $48.0M, narrower than the previous quarter's $59.4M loss.

Operating cash flow was −$32.4M. Non-cash charges added back $1.7M of depreciation and amortization and $24.6M of share-based compensation. Working capital and other items used $10.8M. Capital expenditures of $13K exceeded it, leaving free cash flow of −$32.4M.

Questions

What was Axsome Therapeutics' revenue in the second quarter 2025?

Axsome Therapeutics (AXSM) reported revenue of $150M for the second quarter 2025 (Q2 2025), +72% from a year earlier and +24% from the quarter before.

Was Axsome Therapeutics profitable in the second quarter 2025?

Operating loss was $36.7M (-24.5% of revenue) and net loss $48.0M.

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Source: Axsome Therapeutics 10-Q on SEC EDGAR.