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Ionis Pharmaceuticals stock timeline

A year of the price with every insider trade, planned sale, earnings report and material 8-K marked

252 sessions−46.8% to $39.42

Ionis Pharmaceuticals (IONS) stock fell 47% over the last 252 sessions, to $39.42. On the way it reported 3 quarters, its insiders filed 5 open-market trades and 9 Form 144 notices of planned sales, and the company filed 3 material 8-Ks. Each is marked on the price and listed with what the stock did next.

IONS: a year of the stock with every disclosure on itIONS: a year of the stock with every disclosure on it$48.82$62.65$76.48$90.32◆2025-11-17 · Material definitive agreement●2026-02-25 · Earnings: beat the EPS estimate by 5.6%◆2026-03-09 · Directors and officers: departures, appointments, pay▼2026-04-16 · Baroldi Joseph sold $419K▼2026-04-16 · Birchler Brian sold $73K▼2026-04-16 · Jenne Kyle sold $368K●2026-04-29 · Earnings: beat the EPS estimate by 60.9%◆2026-06-08 · Directors and officers: departures, appointments, pay▽2026-06-25 · Form 144: Eric Swayze plans to sell $839K▽2026-06-26 · Form 144: Mariana Baroldi plans to sell $452K▽2026-06-26 · Form 144: Patrick R. O'Neil plans to sell $246K▽2026-06-26 · Form 144: Eugene Schneider plans to sell $3.9M▽2026-07-01 · Form 144: Joseph III Klein plans to sell $910K▽2026-07-07 · Form 144: Allene M. Diaz plans to sell $864K▽2026-07-07 · Form 144: Holly Kordasiewicz plans to sell $108K▽2026-07-07 · Form 144: C Frank Bennett plans to sell $5.7M●2026-07-29 · Earnings: beat the EPS estimate by 51.7%▲2026-07-30 · Hayden Michael R bought $801K▲2026-07-31 · Hayden Michael R bought $258K▽2026-10-16 · Form 144: Shannon L. Devers plans to sell $60K◆8-K event●Earnings report▼Insider sale▽Planned sale (Form 144)▲Insider buy2025-11-062026-11-06
Daily closes, Nov 6, 2025 to Nov 6, 2026; hover a mark for the filing.

Each mark, and what followed

DateKindWhatNext session5 sessions21 sessions
Oct 16, 2026Form 144Form 144: Shannon L. Devers plans to sell $60K−2.7% (−1.6% vs SPY)−0.5% (+0.6% vs SPY)—
Jul 31, 2026Insider buyHayden Michael R bought $258K−2.9% (−3.6% vs SPY)+2.2% (−1.3% vs SPY)+13.6% (+9.9% vs SPY)
Jul 30, 2026Insider buyHayden Michael R bought $801K−1.4% (−3.1% vs SPY)+0.3% (−5.1% vs SPY)+14.4% (+8.9% vs SPY)
Jul 29, 2026EarningsEarnings: beat the EPS estimate by 51.7%−2.3% (−0.8% vs SPY)−0.4% (−4.5% vs SPY)+13.6% (+10.2% vs SPY)
Jul 7, 2026Form 144Form 144: C Frank Bennett plans to sell $5.7M+3.7% (+4.2% vs SPY)−38.2% (−37.9% vs SPY)−41.2% (−43.9% vs SPY)
Jul 7, 2026Form 144Form 144: Holly Kordasiewicz plans to sell $108K+3.7% (+4.2% vs SPY)−38.2% (−37.9% vs SPY)−41.2% (−43.9% vs SPY)
Jul 7, 2026Form 144Form 144: Allene M. Diaz plans to sell $864K+3.7% (+4.2% vs SPY)−38.2% (−37.9% vs SPY)−41.2% (−43.9% vs SPY)
Jul 1, 2026Form 144Form 144: Joseph III Klein plans to sell $910K−0.1% (0.0% vs SPY)+6.3% (+6.5% vs SPY)−39.8% (−39.1% vs SPY)
Jun 26, 2026Form 144Form 144: Eugene Schneider plans to sell $3.9M+3.6% (+4.3% vs SPY)+4.3% (+2.9% vs SPY)−33.7% (−34.3% vs SPY)
Jun 26, 2026Form 144Form 144: Patrick R. O'Neil plans to sell $246K+3.6% (+4.3% vs SPY)+4.3% (+2.9% vs SPY)−33.7% (−34.3% vs SPY)
Jun 26, 2026Form 144Form 144: Mariana Baroldi plans to sell $452K+3.6% (+4.3% vs SPY)+4.3% (+2.9% vs SPY)−33.7% (−34.3% vs SPY)
Jun 25, 2026Form 144Form 144: Eric Swayze plans to sell $839K+2.3% (+2.2% vs SPY)+3.4% (+1.7% vs SPY)−30.3% (−31.0% vs SPY)
Jun 8, 20268-KDirectors and officers: departures, appointments, pay−1.3% (−1.5% vs SPY)−1.6% (−2.2% vs SPY)+12.6% (+11.3% vs SPY)
Apr 29, 2026EarningsEarnings: beat the EPS estimate by 60.9%+4.2% (+4.2% vs SPY)+4.7% (+3.0% vs SPY)+7.4% (+1.6% vs SPY)
Apr 16, 2026Insider saleJenne Kyle sold $368K−2.1% (−2.3% vs SPY)−2.6% (−4.2% vs SPY)−1.5% (−8.2% vs SPY)
Apr 16, 2026Insider saleBirchler Brian sold $73K−2.1% (−2.3% vs SPY)−2.6% (−4.2% vs SPY)−1.5% (−8.2% vs SPY)
Apr 16, 2026Insider saleBaroldi Joseph sold $419K−2.1% (−2.3% vs SPY)−2.6% (−4.2% vs SPY)−1.5% (−8.2% vs SPY)
Mar 9, 20268-KDirectors and officers: departures, appointments, pay+1.8% (+0.9% vs SPY)−3.9% (−2.4% vs SPY)−0.2% (+1.5% vs SPY)
Feb 25, 2026EarningsEarnings: beat the EPS estimate by 5.6%−5.4% (−6.3% vs SPY)−8.3% (−7.3% vs SPY)−16.2% (−11.9% vs SPY)
Nov 17, 20258-KMaterial definitive agreement+1.7% (+2.5% vs SPY)+6.9% (+6.5% vs SPY)+5.1% (+4.2% vs SPY)

Insiders’ record here

In the year on the chart, Ionis Pharmaceuticals' insiders reported 2 open-market buys ($1.1M) and 3 sales ($860K). Of the 5 old enough to score, 3 were followed by the stock doing what the trade implied over the next 63 sessions (beating SPY after a buy, lagging it after a sale); the median excess return after a buy was −17.2% and after a sale −33.7%.

Across the whole universe (19,782 scored trades), insider buys beat the market 46% of the time and sales were followed by a lagging stock 61% of the time; buys of $1M or more 39%. Every pattern →

What this kind of 8-K usually did

Item8-KsNext session, medianUp next session21 sessions, medianTypical size
1.01 Material definitive agreement23,5250.0%51%+1.0%±1.4%
2.03 New debt or off-balance-sheet obligation13,2680.0%50%+1.2%±1.3%
5.02 Directors and officers: departures, appointments, pay39,174−0.1%48%+0.7%±1.4%

Across every company in the move-odds universe, measured from the close before the filing. Every 8-K item ranked →

Report card: every quarter against the estimate → Ionis Pharmaceuticals: every quarter → Live insider trades →

Prices are daily closes; filings and trades are as filed with the SEC (Form 4 within two business days of the trade, 8-K within four of the event). Moves after a mark are the stock's close-to-close change and the same for SPY; they describe the record, not what the next one will do. Not investment advice.