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Rhythm Pharmaceuticals (RYTM) Q2 2025 earnings results (second quarter 2025)

10-Q filed Aug 5, 2025

Rhythm Pharmaceuticals (RYTM) reported revenue of $48.5M for the second quarter 2025 (Q2 2025), +67% from a year earlier and +48% from the quarter before. Operating margin was -93.4%, net loss $46.6M (96.1% of revenue).

Revenue$48.5M
Year over year+67%
Quarter over quarter+48%
Operating margin-93.4%
Net earnings−$46.6M

Rhythm Pharmaceuticals, Q2 2025: revenue $48.5M (+67% year over year), operating margin -93.4%, net loss $46.6M, operating cash flow −$23.3M. The chart follows the revenue to costs, profit and cash.

Q2 2025AmountQ/QY/Y
Revenue$48.5M+48%+67%
Operating profit−$45.3M——
Net earnings−$46.6M——
Operating cash flow−$23.3M——

What changed

Revenue was $48.5M in Q2 2025, up 67% year over year and up 48% from the previous quarter.

Operating costs exceeded revenue by $45.3M, an operating margin of -93.4%. Total costs grew 35% against revenue growth of 67%. The fastest-growing cost line was Cost of revenue (+88%). The quarter ended with a net loss of $46.6M, narrower than the previous quarter's $49.5M loss.

Operating cash flow was −$23.3M. Non-cash charges added back $15.9M of share-based compensation. Working capital and other items added $7.4M.

Questions

What was Rhythm Pharmaceuticals' revenue in the second quarter 2025?

Rhythm Pharmaceuticals (RYTM) reported revenue of $48.5M for the second quarter 2025 (Q2 2025), +67% from a year earlier and +48% from the quarter before.

Was Rhythm Pharmaceuticals profitable in the second quarter 2025?

Operating loss was $45.3M (-93.4% of revenue) and net loss $46.6M.

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Source: Rhythm Pharmaceuticals 10-Q on SEC EDGAR.