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Rhythm Pharmaceuticals (RYTM) Q3 2025 earnings results (third quarter 2025)

10-Q filed Nov 4, 2025

Rhythm Pharmaceuticals (RYTM) reported revenue of $51.3M for the third quarter 2025 (Q3 2025), +54% from a year earlier and +6% from the quarter before. Operating margin was -102.6%, net loss $52.9M (103.1% of revenue).

Revenue$51.3M
Year over year+54%
Quarter over quarter+6%
Operating margin-102.6%
Net earnings−$52.9M

Rhythm Pharmaceuticals, Q3 2025: revenue $51.3M (+54% year over year), operating margin -102.6%, net loss $52.9M, operating cash flow −$26.6M. The chart follows the revenue to costs, profit and cash.

Q3 2025AmountQ/QY/Y
Revenue$51.3M+6%+54%
Operating profit−$52.7M——
Net earnings−$52.9M——
Operating cash flow−$26.6M——

What changed

Revenue was $51.3M in Q3 2025, up 54% year over year and up 6% from the previous quarter.

Operating costs exceeded revenue by $52.7M, an operating margin of -102.6%. Total costs grew 35% against revenue growth of 54%. The fastest-growing cost line was SG&A (+48%). The quarter ended with a net loss of $52.9M, wider than the previous quarter's $46.6M loss.

Operating cash flow was −$26.6M. Non-cash charges added back $18.8M of share-based compensation. Working capital and other items added $7.5M.

Questions

What was Rhythm Pharmaceuticals' revenue in the third quarter 2025?

Rhythm Pharmaceuticals (RYTM) reported revenue of $51.3M for the third quarter 2025 (Q3 2025), +54% from a year earlier and +6% from the quarter before.

Was Rhythm Pharmaceuticals profitable in the third quarter 2025?

Operating loss was $52.7M (-102.6% of revenue) and net loss $52.9M.

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Source: Rhythm Pharmaceuticals 10-Q on SEC EDGAR.