Filing Flows › Septerna (SEPN) › Q3 2026
Septerna (SEPN) Q3 2026 earnings results (third quarter 2026)
10-Q filed Nov 9, 2026
Septerna (SEPN) reported revenue of $18.9M for the third quarter 2026 (Q3 2026), -12% from a year earlier and -29% from the quarter before. Operating margin was -144.2%, net loss $26.6M (140.8% of revenue).
Septerna, Q3 2026: revenue $18.9M (-12% year over year), operating margin -144.2%, net loss $26.6M, operating cash flow −$13.8M. The chart follows the revenue to costs, profit and cash.
| Q3 2026 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $18.9M | -29% | -12% |
| Operating profit | −$27.2M | — | -1142% |
| Net earnings | −$26.6M | — | -425% |
| Operating cash flow | −$13.8M | — | -108% |
What changed
Revenue was $18.9M in Q3 2026, down 12% year over year and down 29% from the previous quarter.
Operating costs exceeded revenue by $27.2M, an operating margin of -144.2%. Total costs grew 144% against a revenue fall of 12%. The quarter ended with a net loss of $26.6M, wider than the previous quarter's $13.0M loss. Non-operating items added $5.3M, so the bottom line overstates operating performance.
Operating cash flow was −$13.8M. Non-cash charges added back $394K of depreciation and amortization and $5.9M of share-based compensation. Working capital and other items added $6.5M. Capital expenditures of $127K exceeded it, leaving free cash flow of −$13.9M.
Questions
What was Septerna's revenue in the third quarter 2026?
Septerna (SEPN) reported revenue of $18.9M for the third quarter 2026 (Q3 2026), -12% from a year earlier and -29% from the quarter before.
Was Septerna profitable in the third quarter 2026?
Operating loss was $27.2M (-144.2% of revenue) and net loss $26.6M.
Source: Septerna 10-Q on SEC EDGAR.