Filing Flows › Comparisons › HRMY vs IONS
Harmony Biosciences Holdings vs Ionis Pharmaceuticals: HRMY and IONS compared
Harmony Biosciences Holdings is the larger company: $269M of revenue in its latest quarter (Q3 2026) against $268M for Ionis Pharmaceuticals (Q2 2026). Harmony Biosciences Holdings is growing faster (+12% against -41% a year earlier). Harmony Biosciences Holdings is more profitable, with an operating margin of 20.2% against -38.2%.
Where the money goes: HRMY and IONS
Harmony Biosciences Holdings (HRMY) · Q3 2026
Harmony Biosciences Holdings, Q3 2026: revenue $269M (+12% year over year), operating margin 20.2%, net earnings $48.2M, operating cash flow $76.7M. The chart follows the revenue to costs, profit and cash.
Ionis Pharmaceuticals (IONS) · Q2 2026
Ionis Pharmaceuticals, Q2 2026: revenue $268M (-41% year over year), operating margin -38.2%, net loss $115M, operating cash flow $566M. The chart follows the revenue to costs, profit and cash.
| Harmony Biosciences Holdings (HRMY) | Ionis Pharmaceuticals (IONS) | |
|---|---|---|
| Latest quarter | Q3 2026 | Q2 2026 |
| Revenue | $269M | $268M |
| Revenue growth, Y/Y | +12% | -41% |
| Gross margin | 70.0% | — |
| Operating margin | 20.2% | -38.2% |
| Net earnings | $48.2M | −$115M |
| Net margin | 17.9% | -42.8% |
| Operating cash flow | $76.7M | $566M |
| Free cash flow | — | $549M |
| Market value | — | $7.1B |
| Analysts’ mean target | — | $84.13 |
Where the revenue comes from
Ionis Pharmaceuticals
- Research and Development Revenue: $150M (56%)
- Royalty: $76.0M (28%)
- DAWNZERASales: $26.6M (10%)
- Other Commercial: $11.5M (4%)
Questions
Which is bigger, Harmony Biosciences Holdings or Ionis Pharmaceuticals?
Harmony Biosciences Holdings is the larger company: $269M of revenue in its latest quarter (Q3 2026) against $268M for Ionis Pharmaceuticals (Q2 2026).
Is Harmony Biosciences Holdings or Ionis Pharmaceuticals growing faster?
Harmony Biosciences Holdings is growing faster (+12% against -41% a year earlier).
Which is more profitable, Harmony Biosciences Holdings or Ionis Pharmaceuticals?
Harmony Biosciences Holdings is more profitable, with an operating margin of 20.2% against -38.2%.
More: Harmony Biosciences Holdings earnings · how Harmony Biosciences Holdings makes money · Ionis Pharmaceuticals earnings · how Ionis Pharmaceuticals makes money
From the companies' latest 10-Q, 10-K or earnings release (10-Q filed Nov 4, 2026; 10-Q filed Jul 29, 2026). Fiscal quarters can end on different dates. Not investment advice.