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Prelude Therapeutics (PRLD) earnings and revenue breakdown

Latest: Q2 2026 · 10-Q filed Aug 11, 2026 · Prelude Therapeutics (PRLD) Q2 2026 earnings results →

Q2 2026 244¢ of every $1 of revenue lost · operating margin -270.9%

Prelude Therapeutics made $5.7M in Q2 2026. Operating margin -270.9%, net loss $13.9M. See where every dollar goes — costs, profit and cash — as a Sankey from the 10-Q filed Aug 11, 2026.

Revenue$5.7M
Year over year—
Operating margin-270.9%
Net earnings−$13.9M
Operating cash flow−$15.6M

Drawing the Sankey…

Open the interactive Sankey → click any line for what the company wrote about it, compare Y/Y and Q/Q, export as PNG or PDF

What changed this quarter

Revenue was $5.7M in Q2 2026, up 25% from the previous quarter.

Operating costs exceeded revenue by $15.5M, an operating margin of -270.9%. The quarter ended with a net loss of $13.9M, wider than the previous quarter's $10.4M loss.

Operating cash flow was −$15.6M. Non-cash charges added back $353K of depreciation and amortization and $2.0M of share-based compensation. Working capital and other items used $4.0M.

Quarterly history

Prelude Therapeutics revenue by quarterPrelude Therapeutics revenue by quarter$4.0MQ4 2024$6.5MQ3 2025$5.6MQ4 2025$4.6MQ1 2026$5.7MQ2 2026
Prelude Therapeutics net earnings by quarterPrelude Therapeutics net earnings by quarter−$28.7MQ4 2024−$19.7MQ3 2025−$16.5MQ4 2025−$10.4MQ1 2026−$13.9MQ2 2026
QuarterFormFiledRevenueY/YOp. marginNet earningsOp. cash flow
Q2 202610-QAug 11, 2026$5.7M—-270.9%−$13.9M−$15.6M
Q1 202610-QMay 12, 2026$4.6M—-309.5%−$10.4M−$21.7M
Q4 202510-KMar 10, 2026$5.6M+41%-307.6%−$16.5M$23.1M
Q3 202510-QNov 12, 2025$6.5M+117%-314.1%−$19.7M−$19.1M
Q4 202410-KMar 10, 2025$4.0M—-845.8%−$28.7M−$20.7M

Charts

Prelude Therapeutics: revenue growth, year over year and quarter over quarterPrelude Therapeutics: revenue growth, year over year and quarter over quarterY/YQ/Q+117%+62%Q3 2025+41%-13%Q4 2025-19%Q1 2026+25%Q2 2026
Latest (Q2 2026): Y/Y —, Q/Q +25%.
Prelude Therapeutics: where the cash came from (+) and went (−), TTM to Q2 2026Prelude Therapeutics: where the cash came from (+) and went (−), TTM to Q2 2026Other financing$110MOther investing−$77.3MOperating cash flow−$33.3MShares issued$132KTaxes on employees’ shares−$74KCash drawn (+) / kept (−)$62K
From the cash-flow statement as filed (SEC XBRL). Cash is fungible: the bars do not say which dollar paid for what.
Prelude Therapeutics: profit against cash, quarter by quarterPrelude Therapeutics: profit against cash, quarter by quarterNet incomeOperating cash flow−$32.3M−$27.3MQ3 2024−$28.7M−$20.7MQ4 2024−$32.1M−$34.2MQ1 2025−$31.2M−$26.1MQ2 2025−$19.7M−$19.1MQ3 2025−$16.5M$23.1MQ4 2025−$10.4M−$21.7MQ1 2026−$13.9M−$15.6MQ2 2026
Latest (Q2 2026): Net income −$13.9M, Operating cash flow −$15.6M.
Prelude Therapeutics: diluted shares by fiscal year (split-adjusted)Prelude Therapeutics: diluted shares by fiscal year (split-adjusted)50MFY202046MFY202147MFY202260MFY202376MFY202477MFY2025
+54.2% since FY2020: more shares outstanding (issuance, stock pay); earlier years scaled for the 4-for-1 split before FY2021.

Interactive views

The same charts as the app — open one to draw it.

💵Where each $1 goesinteractive

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🌏Named in Asian annual reportsinteractive

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🔄Rotation against the market and its industry (RRG)interactive

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🔍Earnings qualityinteractive

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⚖️Fair value by methodinteractive

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🔭Outlook & guidanceinteractive

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📈Investments: gains and what it boughtinteractive

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🏭Its industry’s money flow (input-output)interactive

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About Prelude Therapeutics

Prelude Therapeutics is a leading precision oncology company developing innovative medicines in areas of high unmet need for cancer patients. Our pipeline features highly selective KAT6A degraders and JAK2V617F mutant selective inhibitors -- new approaches to clinically validated targets with transformative potential for patients. We are leveraging our expertise in targeted protein degradation to create and develop next generation degrader antibody conjugates (DACs) with novel payloads. We are on a mission to extend the promise of precision medicine to every cancer patient in need. For more information, visit preludetx.com.

In its own words, from its 8-K, filed Aug 11, 2026.

Prelude Therapeutics against its Pharmaceutical Preparations peers

The largest companies of the same SEC industry, each at its latest quarter. Operating margin: -270.9% against the peers' median 20.4%.

CompanyQuarterRevenueY/YOp. margin
PRLD Prelude TherapeuticsQ2 2026$5.7M—-270.9%
JNJ Johnson & JohnsonQ3 2026$25.4B+6%0.1%
LLY ELI LillyQ3 2026$24.4B+39%34.5%
MRK MerckQ3 2026$18.1B+5%30.7%
ABBV AbbVieQ3 2026$17.4B+10%36.0%
PFE PfizerQ3 2026$16.6B-0.4%20.4%
BMY Bristol Myers SquibbQ3 2026$13.1B+7%19.4%
ABT Abbott LaboratoriesQ3 2026$13.0B+14%10.4%
REGN Regeneron PharmaceuticalsQ3 2026$5.1B+36%40.0%

Source: Prelude Therapeutics 10-Q on SEC EDGAR · CIK 1678660 · Pharmaceutical Preparations

13F: who owns PRLD and who is buying

Largest holders of PRLD (13F)Largest holders of PRLD (13F)Orbimed Advisors LLC$73.2MBaker Bros. Advisors LP$54.0MRA Capital Management, L.P.$34.5MSoleus Capital Management, L.P.$18.0MKynam Capital Management, LP$12.9MVanguard Capital Management LLC$10.7MBlackRock$9.6MSphera Funds Management$5.4MTwo Sigma Investments, LP$5.3MADAR1 Capital Management, LLC$4.8M
Funds' net buying of PRLD by quarter (13F)Funds' net buying of PRLD by quarter (13F)$500K2024-09−$4.9M2024-12−$1.2M2025-03−$2.8M2025-06$237K2025-09$3.9M2025-12$8.2M2026-03$45.7M2026-06
Value of shares 13F filers added minus the value they sold, each quarter (quarters with most filings in).

More on PRLD

History

Every quarter: Q2 2026 results · Q1 2026 results · Q4 2025 results · Q3 2025 results · Q4 2024 results

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