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Prelude Therapeutics (PRLD) Q1 2026 earnings results (first quarter 2026)

10-Q filed May 12, 2026

Prelude Therapeutics (PRLD) reported revenue of $4.6M for the first quarter 2026 (Q1 2026) and -19% from the quarter before. Operating margin was -309.5%, net loss $10.4M (226.7% of revenue).

Revenue$4.6M
Year over year—
Quarter over quarter-19%
Operating margin-309.5%
Net earnings−$10.4M

Prelude Therapeutics, Q1 2026: revenue $4.6M, operating margin -309.5%, net loss $10.4M, operating cash flow −$21.7M. The chart follows the revenue to costs, profit and cash.

Q1 2026AmountQ/QY/Y
Revenue$4.6M-19%—
Operating profit−$14.2M——
Net earnings−$10.4M——
Operating cash flow−$21.7M-194%—

What changed

Revenue was $4.6M in Q1 2026, down 19% from the previous quarter.

Operating costs exceeded revenue by $14.2M, an operating margin of -309.5%. The quarter ended with a net loss of $10.4M, narrower than the previous quarter's $16.5M loss. Non-operating items added $3.8M, -37% of pre-tax earnings, so the bottom line overstates operating performance.

Operating cash flow was −$21.7M. Non-cash charges added back $391K of depreciation and amortization and $2.0M of share-based compensation. Working capital and other items used $13.7M.

Questions

What was Prelude Therapeutics' revenue in the first quarter 2026?

Prelude Therapeutics (PRLD) reported revenue of $4.6M for the first quarter 2026 (Q1 2026) and -19% from the quarter before.

Was Prelude Therapeutics profitable in the first quarter 2026?

Operating loss was $14.2M (-309.5% of revenue) and net loss $10.4M.

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Source: Prelude Therapeutics 10-Q on SEC EDGAR.