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Personalis (PSNL) Q2 2025 earnings results (second quarter 2025)

10-Q filed Aug 5, 2025

Personalis (PSNL) reported revenue of $17.2M for the second quarter 2025 (Q2 2025), -24% from a year earlier and -17% from the quarter before. Operating margin was -126.7%, net loss $20.1M (116.6% of revenue).

Revenue$17.2M
Year over year-24%
Quarter over quarter-17%
Operating margin-126.7%
Net earnings−$20.1M

Personalis, Q2 2025: revenue $17.2M (-24% year over year), operating margin -126.7%, net loss $20.1M, operating cash flow −$12.9M. The chart follows the revenue to costs, profit and cash.

Q2 2025AmountQ/QY/Y
Revenue$17.2M-17%-24%
Operating profit−$21.8M——
Net earnings−$20.1M——
Operating cash flow−$12.9M——

What changed

Revenue was $17.2M in Q2 2025, down 24% year over year and down 17% from the previous quarter.

Operating costs exceeded revenue by $21.8M, an operating margin of -126.7%. Total costs fell 1% while revenue fell 24%. The fastest-growing cost line was SG&A (+18%). The quarter ended with a net loss of $20.1M, wider than the previous quarter's $15.8M loss.

Operating cash flow was −$12.9M. Non-cash charges added back $2.5M of depreciation and amortization and $2.8M of share-based compensation. Working capital and other items added $1.8M. Capital expenditures of $290K exceeded it, leaving free cash flow of −$13.2M.

Questions

What was Personalis' revenue in the second quarter 2025?

Personalis (PSNL) reported revenue of $17.2M for the second quarter 2025 (Q2 2025), -24% from a year earlier and -17% from the quarter before.

Was Personalis profitable in the second quarter 2025?

Operating loss was $21.8M (-126.7% of revenue) and net loss $20.1M.

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Source: Personalis 10-Q on SEC EDGAR.