Filing Flows › Personalis (PSNL) › Q4 2025
Personalis (PSNL) Q4 2025 earnings results (fourth quarter 2025)
10-K filed Feb 26, 2026
Personalis (PSNL) reported revenue of $17.3M for the fourth quarter 2025 (Q4 2025), +3% from a year earlier and +20% from the quarter before. Operating margin was -145.7%, net loss $23.8M (137.3% of revenue).
Personalis, Q4 2025: revenue $17.3M (+3% year over year), operating margin -145.7%, net loss $23.8M, operating cash flow −$22.2M. The chart follows the revenue to costs, profit and cash.
| Q4 2025 | Amount | Q/Q | Y/Y |
|---|---|---|---|
| Revenue | $17.3M | +20% | +3% |
| Operating profit | −$25.3M | — | — |
| Net earnings | −$23.8M | — | — |
| Operating cash flow | −$22.2M | — | — |
What changed
Revenue was $17.3M in Q4 2025, up 3% year over year and up 20% from the previous quarter.
Operating costs exceeded revenue by $25.3M, an operating margin of -145.7%. Total costs grew 22% against revenue growth of 3%. The fastest-growing cost line was SG&A (+26%). The quarter ended with a net loss of $23.8M, wider than the previous quarter's $21.7M loss.
Operating cash flow was −$22.2M. Non-cash charges added back $2.5M of depreciation and amortization and $2.3M of share-based compensation. Working capital and other items used $3.2M. Capital expenditures of $77K exceeded it, leaving free cash flow of −$22.3M.
Questions
What was Personalis' revenue in the fourth quarter 2025?
Personalis (PSNL) reported revenue of $17.3M for the fourth quarter 2025 (Q4 2025), +3% from a year earlier and +20% from the quarter before.
Was Personalis profitable in the fourth quarter 2025?
Operating loss was $25.3M (-145.7% of revenue) and net loss $23.8M.
Source: Personalis 10-K on SEC EDGAR.