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Maze Therapeutics (MAZE) earnings and revenue breakdown

Latest: Q1 2026 · 10-Q filed May 12, 2026 · Maze Therapeutics (MAZE) Q1 2026 earnings results →

Q1 2026 121¢ of every $1 of revenue lost · operating margin -132.8%

Maze Therapeutics made $20.0M in Q1 2026. Operating margin -132.8%, net loss $24.2M. See where every dollar goes — costs, profit and cash — as a Sankey from the 10-Q filed May 12, 2026.

Revenue$20.0M
Year over year—
Operating margin-132.8%
Net earnings−$24.2M
Operating cash flow−$39.1M

Drawing the Sankey…

Open the interactive Sankey → click any line for what the company wrote about it, compare Y/Y and Q/Q, export as PNG or PDF

What changed this quarter

Revenue was $20.0M in Q1 2026.

Operating costs exceeded revenue by $26.6M, an operating margin of -132.8%. The quarter ended with a net loss of $24.2M.

Operating cash flow was −$39.1M. Non-cash charges added back $444K of depreciation and $7.1M of share-based compensation. Working capital and other items used $22.5M. Capital expenditures of $93K exceeded it, leaving free cash flow of −$39.2M.

Quarterly history

QuarterFormFiledRevenueY/YOp. marginNet earningsOp. cash flow
Q1 202610-QMay 12, 2026$20.0M—-132.8%−$24.2M−$39.1M

Charts

Maze Therapeutics: where the cash came from (+) and went (−), TTM to Q2 2026Maze Therapeutics: where the cash came from (+) and went (−), TTM to Q2 2026Other financing$326MOther investing−$292MOperating cash flow−$107MCash drawn (+) / kept (−)$61.9MShares issued$11.2MCapital spending−$302K
From the cash-flow statement as filed (SEC XBRL). Cash is fungible: the bars do not say which dollar paid for what.
Maze Therapeutics: profit against cash, quarter by quarterMaze Therapeutics: profit against cash, quarter by quarterNet incomeOperating cash flow−$24.8M−$23.2MQ3 2024−$29.6M−$22.5MQ4 2024−$32.8M−$29.5MQ1 2025−$33.7M−$30.1MQ2 2025−$30.1M−$24.6MQ3 2025−$34.6M−$27.7MQ4 2025−$24.2M−$39.1MQ1 2026−$44.7M−$15.1MQ2 2026
Latest (Q2 2026): Net income −$44.7M, Operating cash flow −$15.1M.

Interactive views

The same charts as the app — open one to draw it.

💵Where each $1 goesinteractive

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🌏Named in Asian annual reportsinteractive

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🔄Rotation against the market and its industry (RRG)interactive

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🔍Earnings qualityinteractive

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⚖️Fair value by methodinteractive

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🔭Outlook & guidanceinteractive

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📈Investments: gains and what it boughtinteractive

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🏭Its industry’s money flow (input-output)interactive

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About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel small molecule precision medicines for patients with kidney and metabolic diseases. Guided by its Compass™ platform, Maze pursues genetically validated targets by integrating variant discovery and functionalization to discover and advance small molecule programs with first- or best-in-class potential. Maze’s pipeline is led by MZE829, a dual-mechanism APOL1 inhibitor in Phase 2 development for APOL1-mediated kidney disease (AMKD), and MZE782, a SLC6A19 inhibitor in Phase 2 development with the potential to treat both phenylketonuria (PKU) and chronic kidney disease (CKD). Maze is headquartered in South San Francisco. For more information, please visit mazetx.com , or follow Maze on LinkedIn and X .

In its own words, from its 8-K, filed Aug 11, 2026.

Maze Therapeutics against its Biological Products, (No Diagnostic Substances) peers

The largest companies of the same SEC industry, each at its latest quarter. Operating margin: -132.8% against the peers' median 35.8%.

CompanyQuarterRevenueY/YOp. margin
MAZE Maze TherapeuticsQ1 2026$20.0M—-132.8%
AMGN AmgenQ3 2026$10.4B+8%35.8%
GILD Gilead SciencesQ3 2026$8.3B+7%41.7%
BIIB BiogenQ3 2026$2.8B+11%-0.3%
MRNA ModernaQ3 2026$1.3B+29%9.9%
NBIX Neurocrine BiosciencesQ3 2026$1.1B+41%29.5%
EXEL ExelixisQ3 2026$659M+10%40.8%
HALO Halozyme TherapeuticsQ3 2026$493M+39%59.8%
MGTX MeiraGTx HoldingsQ2 2026$321M87×76.0%

Source: Maze Therapeutics 10-Q on SEC EDGAR · CIK 1842295 · Biological Products, (No Diagnostic Substances)

13F: who owns MAZE and who is buying

Largest holders of MAZE (13F)Largest holders of MAZE (13F)Frazier Life Sciences Management,…$150MTRV GP IV, LLC$134MArch Venture Management, LLC$123MDeep Track Capital, LP$111MBlackRock$105MJupiter Topco LLC$102MJanus Henderson Group$85.3MT. Rowe Price Investment Manageme…$77.7MVanguard Group$70.3MLogos Global Management LP$57.7M
Funds' net buying of MAZE by quarter (13F)Funds' net buying of MAZE by quarter (13F)$440M2025-03−$14.7M2025-06$102M2025-09$198M2025-12$83.3M2026-03$110M2026-06
Value of shares 13F filers added minus the value they sold, each quarter (quarters with most filings in).

More on MAZE

History

Every quarter: Q1 2026 results

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